ReviewAdvances in experimental medicine and biology2025
Circular RNAs Regulate Transcription and Translation.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- CircLRIG1 inhibits the malignant phenotypes of colorectal cancer cells by inactivating the NF-κB signaling through interaction with FUS.Discover oncology · 2026Article
- Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are non-coding RNAs that are single-stranded and closed covalently. They are found in various organisms, from viruses to mammals. CircRNAs are involved in diverse biological processes, functioning as microRNA (miRNA) decoys and transcriptional modulators and interacting with RNA-binding proteins. Recent studies have shown that certain cytoplasmic circRNAs are capable of being translated into peptides. This discovery has shed light on the significance of circRNAs in cellular physiological processes. Moreover, there are several potential mechanisms for circRNA translation, including internal ribosome entry site (IRES)-driven translation and N6-methyladenosines (m6A)-mediated cap-independent translation. Thus, it indicates that circRNAs have a diverse role in regulating biological processes, particularly in various diseases. Furthermore, multiple studies have shown that circRNAs display unique expression patterns and play crucial roles in multiple diseases, suggesting their potential utility as diagnostic biomarkers and targets for therapeutic intervention.
Indexed as
Identifiers
40886276What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.