Evidence map›Paper›PMID 40886273›Full record

ReviewAdvances in experimental medicine and biology2025

RNA-Binding Proteins (RBPs) and Circular RNA Biogenesis.

Shasha Shi, Rui Zhao

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shasha ShiDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rui ZhaoDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. rui.zhao@cuanschutz.edu.

Funding

The molecular mechanism of pre-mRNA splicingR35GM145289 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI RUI ZHAO · 2022 to 2026
$4.3M
Understanding the structure and function of U1 snRNPR01GM126157 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ZHAO, RUI · 2018 to 2021
$1.8M
Structure and function of spliceosomeR01GM130673 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ZHAO, RUI · 2019 to 2021
$1.3M
NIGMS NIH HHS R01 GM126157NIGMS NIH HHS R01 GM130673NIGMS NIH HHS R35 GM145289
6 · The paper itself

Abstract

Many protein-coding genes in eukaryotes have the capacity to produce circular RNAs (circRNAs). CircRNAs are stable and covalently closed products generated from backsplicing. Their biogenesis is regulated by multiple factors, with RNA-binding proteins (RBPs) playing a critical role. RBPs bind to flanking introns of the circularizing exons, bringing the intervening splice site into close proximity and thereby facilitating the process of backsplicing. In this chapter, we summarize the literature on RBP-mediated circularization in circRNA biogenesis, illustrating how RBPs influence RNA fate and gene regulation.

Indexed as

RNARNA-Binding ProteinsAnimalsExonsGene Expression RegulationHumansIntronsRNA, CircularRNA SplicingRNARNA-Binding ProteinsRNA, CircularBacksplicingBiogenesisCircRNARNA-binding proteins

Identifiers

PMID40886273
PMCPMC13105153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.