Evidence map›Paper›PMID 40886237›Full record

ArticleInfectious diseases and therapy2025

RSV Testing Patterns and Characteristics Associated with RSV Testing Among Adults Aged 50 Years or Older in the United States.

David Singer, Emily K Horn, Yan Wang, Aozhou Wu, Elizabeth M La, Susan I Gerber, Joanna Boland, Keith A Betts

Abstract read
In one paragraph

Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David SingerGSK, FMC Tower, Suite 1700, 2929 Walnut Street, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-8008-8003
Emily K HornGSK, FMC Tower, Suite 1700, 2929 Walnut Street, Philadelphia, PA, 19104, USA. emily.k.horn@gsk.com.ORCID http://orcid.org/0000-0002-2491-7134
Yan WangAnalysis Group, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9326-0148
Aozhou WuAnalysis Group, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7066-0408
Elizabeth M LaGSK, FMC Tower, Suite 1700, 2929 Walnut Street, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-5652-8961
Susan I GerberGSK, FMC Tower, Suite 1700, 2929 Walnut Street, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0009-0003-0927-573X
Joanna BolandAnalysis Group, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7858-979X
Keith A BettsAnalysis Group, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3088-7453

Funding

GSK VEO-000617
6 · The paper itself

Abstract

introductionRespiratory syncytial virus (RSV) is a common respiratory virus that can cause severe disease, particularly in older adults and adults with underlying medical conditions. However, RSV infections often go underdiagnosed due to infrequent testing and assay sensitivity limitations. To better understand RSV epidemiology and disease burden, we investigated respiratory virus testing patterns and characteristics associated with RSV testing among United States (US) adults aged ≥ 50 years with acute respiratory illnesses (ARIs).

methodsThis was a retrospective study using Optum

resultsAmong 22,475,891 included ARIs, RSV testing occurred in 2.4% (n = 530,452) of episodes. RSV testing increased over time (1.3-5.9% from 2016-2017 to 2022-2023 EYs), though it remained markedly lower than influenza (5.8-15.1%; 2016-2017 to 2022-2023 EYs) and SARS-CoV-2 (5.8-22.6%; 2019-2020 to 2022-2023 EYs) testing. By most intensive level of care received, RSV testing from 2016-2023 was more frequent in inpatient (9.5-27.5%) and emergency department (ED; 1.4-17.9%) settings than the outpatient setting (0.3-1.4%). Among included covariates in adjusted analyses, most intensive care setting [ED: 9.3-fold, inpatient: 31.2-fold (versus outpatient)] and healthcare organization (0.02-13.8-fold) were most significantly associated with likelihood of RSV testing.

conclusionThe likelihood of RSV testing varied significantly by most intensive care setting and healthcare organization. Despite increasing RSV testing over time, RSV remains infrequently tested among US adults. Under-detection of medically-attended RSV cases should be accounted for when estimating RSV disease burden and the potential impact of RSV prevention strategies. A Graphical Abstract is available for this article.

Indexed as

Acute respiratory illnessDetectionDiagnosisInfluenzaOlder adultsRespiratory syncytial virusRespiratory virusesSARS-CoV-2Testing

Identifiers

PMID40886237
PMCPMC12480313

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.