Evidence map›Paper›PMID 40886185›Full record

ArticleArchives of toxicology2025

Fluoride intake during pregnancy: calculation of realistic exposure scenarios for individual risk assessment.

A Sonnenburg, M Batke, G Damm, H Foth, A Freyberger, J G Hengstler, A Mangerich, F Partosch, Th Schupp, K-M Wollin and 2 more

Abstract read
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A SonnenburgDepartment Pesticides Safety, German Federal Institute for Risk Assessment, Berlin, Germany. anna.sonnenburg@bfr.bund.de.ORCID 0000-0001-6524-6456
M BatkeUniversity of Applied Sciences Emden/Leer, Emden, Germany.
G DammDepartment of Hepatobiliary Surgery and Visceral Transplantation, Leipzig University Medical Center, Leipzig, Germany.
H FothInstitute of Environmental Toxicology, University of Halle, Halle/Saale, Germany.
A FreybergerFormerly Bayer AG, Wuppertal, Germany.
J G HengstlerLeibniz Research Centre for Working Environment and Human Factors, Dortmund University, Dortmund, Germany.
A MangerichUniversityof Potsdam, Department of Nutritional Toxicology, Institute of Nutritional Science, Potsdam, Germany.
F PartoschRamboll Deutschland GmbH, Essen, Germany.
Th SchuppUniversity of Applied Sciences Muenster, Steinfurt, Germany.
K-M WollinFormerly Public Health Agency of Lower Saxony, Hannover, Germany.
J Vom BrockeEuropean Chemicals Agency, Helsinki, Finland.
U Gundert-RemyCharité-Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using the methodological approach of systematic review several regulatory bodies and associations have performed an assessment of existing evidence on the adverse effects of fluoride. The most recent review by EFSA published in 2025 recommended a fluoride level in drinking water of below 1.5 mg/L and a maximum total daily intake of 3.3 mg of fluoride as safe level with particular respect to pregnant women and the exposed unborn child. Our work focusses on individual exposure aspects, evaluating the contribution of major sources, specifically those which can be influenced by personal behaviour. We demonstrate that black or green tea and fluoridated household salt-even at salt intake levels below the population 25th percentile-are main contributors of the daily fluoride exposure in the population. Using the safe level proposed by EFSA, we have calculated different exposure scenarios that may be used by individuals to estimate their specific exposure to fluoride from known sources. Considering that the safe level proposed by EFSA can be exceeded e.g. by drinking more than two cups (300 mL) of black or green tea daily and using even low amounts of fluoridated salt, our findings highlight the need for clear labelling of the fluoride content of products to allow informed consumer choices.

Indexed as

Dietary ExposureDrinking WaterFluoridesFemaleFluoridationHumansPregnancyRisk AssessmentTeaDrinking WaterFluoridesTeaConsumption of black/green teaExposure assessmentFluoridated saltFluoride health effectsPregnant women

Identifiers

PMID40886185
PMCPMC12534287

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.