ArticleJournal of the American Heart Association2025
Identification of Clinical Phenotypes in Type 2 Myocardial Infarction: Insights Into Characteristics, Prognosis, and Management Strategies.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Contemporary Challenges and Strategies for Diagnosing and Managing in Type 2 Myocardial Infarction: A Narrative Review.Journal of personalized medicine · 2026Review
- Subclinical Atherosclerosis, Hyperlipidemia and New-Onset Diabetes Should Not Be Ignored Despite Initial Angiographic Exclusion of Significant Atherosclerotic Occlusive Arterial Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Introduction of High-Sensitivity Troponin Assay to Rural Tertiary Care Medical Center: Impact on Subsequent Cardiac Diagnostic Testing.Diagnostics (Basel, Switzerland) · 2026Article
- Periprocedural Myocardial Infarction: Do We Need an Updated Definition?Journal of cardiovascular development and disease · 2026Review
- Unsupervised Clustering of Routine Inflammatory Markers in Cardiogenic Shock Reveals Phenotypic Heterogeneity Without Prognostic Utility.Journal of personalized medicine · 2026Article
- Elevated plasma cancer antigen-125 level is associated with increased risk of new-onset atrial fibrillation after acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 myocardial infarction (T2MI) accounts for a substantial share of acute coronary syndromes but remains challenging to diagnose and manage due to its varied presentations and underlying profiles. This study aims to identify key differences and distinct clinical phenotypes in a large T2MI population.
methodsAll consecutive patients with non-ST-segment-elevation myocardial infarction undergoing coronary angiography with a confirmed T2MI diagnosis between January 1, 2017, and March 31, 2023, were analyzed. Precipitating factors of supply-demand mismatch were identified, and coronary burden was assessed using the Gensini score. Latent class analysis was used to identify clinical phenotypes, and multivariable analyses were performed to determine prognostic predictors. A composite of major adverse cardiovascular events was assessed during follow-up, along with additional outcomes including cardiovascular death and nonfatal type 2 reinfarction.
resultsAmong 774 patients with T2MI, latent class analysis identified 2 phenotypes. Phenotype 1 (31.5%) was younger with a higher prevalence of nonatherosclerotic coronary causes and unknown pathogeneses. Phenotype 2 (68.5%) exhibited greater comorbidity and a higher atherosclerotic burden, reflected by elevated Gensini scores (median, 11 versus 1.5;
conclusionsThis study identified 2 clinical phenotypes in T2MI, highlighting differences in characteristics, precipitating factors, outcomes, and prognostic predictors, emphasizing the potential for phenotype-driven approaches in diagnosis and management.
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