Evidence map›Paper›PMID 40886060›Full record

ArticleEuropean heart journal2025

CRISPR activation to repair electrocardiogram abnormalities caused by a FLNC truncating variant in mice.

Rodrigo Cañas-Alvaro, Laura Lalaguna, Blanca Rubio, Antonella Ausiello, Marina López-Olañeta, Rocío F Serrano-Blanco, Juan Pablo Ochoa, Jose Luis de la Pompa, Alejandro Chavez, Pablo García-Pavía and 1 more

Abstract read
In one paragraph

Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Filamin C activates MAPK/ERK signaling to facilitate epithelial-mesenchymal transition in bladder cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodrigo Cañas-AlvaroMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Laura LalagunaMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Blanca RubioMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Antonella AusielloMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Marina López-OlañetaMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Rocío F Serrano-BlancoIntercellular Signalling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Juan Pablo OchoaMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.
Jose Luis de la PompaIntercellular Signalling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Alejandro ChavezDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92123, USA.
Pablo García-PavíaMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.ORCID 0000-0002-5470-2257
Enrique Lara-PezziMyocardial Homeostasis and Cardiac Injury Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernandez Almagro, 3, Madrid 29029, Spain.ORCID 0000-0002-2743-1033

Funding

Methods to Rapidly Explore Combinatorial Diversity and Their Application to CRISPR-Cas9 SystemsDP2NS131566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alejandro Chavez · 2022 to 2026
$2.4M
Burroughs Wellcome FoundationEuropean Union's NextGenerationEUFEDER CB16/11/00399FEDER PID2022-136942OB-I00Instituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y UniversidadesMinistry of Science and InnovationNIH HHS DP2NS131566-01NINDS NIH HHS DP2 NS131566Pathfinder Cardiogenomics programme of the European Innovation Council 101115416Pathfinder Cardiogenomics programme of the European Innovation Council PID2021-124629OB-I00Pathfinder Cardiogenomics programme of the European Innovation Council PLEC2022-009235Pathfinder Cardiogenomics programme of the European Innovation Council TED2021-129774B-C22Plan de Recuperación, Transformación y Resiliencia de EspañaPro CNIC FoundationSevero Ochoa Center of Excellence CEX2020-001041-S
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CardiomyopathyCRISPR activationDilated cardiomyopathyFLNC truncating variantsGene therapyNon-dilated left ventricular cardiomyopathy

Identifiers

PMID40886060
PMCPMC12614992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.