ArticleBMC sports science, medicine & rehabilitation2025
Effects of aerobic combined with resistance exercise on cardiopulmonary function in patients with coronary heart disease: a bayesian meta-analysis based on dose-response, baseline status, and other moderators.
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Combined Aerobic and Resistance Training on Exercise Capacity, Muscle Strength, Quality of Life, and Mortality in Patients with Coronary Heart Disease: A Systematic Review with Meta-analysis.Sports medicine - open · 2026Pooled it
- Baseline peak VO₂ and treatment effect consistency of perioperative rehabilitation in cardiac valve surgery: an exploratory subgroup analysis of the PORT trial.BMC anesthesiology · 2026Trial
- Role of exercise in cardiovascular health: a narrative review from prevention to therapeutic utilizations.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery disease (CHD) is one of the major public health problems worldwide. International guidelines recommend ongoing management of metabolic abnormalities and improved prognosis through combined aerobic and resistance exercise (CE), and the aim of this study was to investigate the effects of CE and exercise dose on cardiorespiratory fitness, as measured by maximum oxygen uptake (VO2max), in patients with CHD.
methodsWe conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science, with the search limited to the date of the inception of the database to January 2025 to identify randomized controlled trials (RCTs). Pairwise and regression meta-analyses of these results were conducted using Bayesian stratified models based on random effects.
resultsThe 12 RCTs included a total of 697 patients. The results show that CE significantly increased the VO2max of coronary heart disease patients compared with the control group that did not exercise (MD = 3.1 ml/kg/min; 95%CrI: 2.57, 3.64; GRADE: Low). In addition, there is a nonlinear positive correlation between the weekly CE dose and the level of improvement in VO2max, with a minimum dose of 310 METs-min/week. The magnitude of VO2max improvement is more pronounced in patients with lower baseline cardiorespiratory fitness and gradually decreases with age.
conclusionCE showed significant benefit in improving cardiorespiratory function in patients with CHD. In addition, even lower doses of CE (≥ 310 MET-min/week) improved cardiorespiratory fitness, and the gain was progressively apparent before reaching a critical threshold. The findings suggest that clinical practice should tailor exercise regimens to patient age and baseline VO2max.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.