SynthesisBMC public health2025
Global air pollution exposure and hepatocellular carcinoma: a systematic review and meta-analysis of epidemiological studies.
Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- PM2.5 promotes migration of hepatocellular carcinoma by targeting miR-25.Translational cancer research · 2026Article
- Air pollution and hepatocellular carcinoma: Integrated network toxicology, machine learning, molecular docking and multiomics analysis.Oncology letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAir pollution poses a significant public health threat worldwide, contributing to adverse health outcomes and reduced life expectancy. Recent research has highlighted a growing interest in understanding the association between air pollution and cancer. This meta-analysis aims to comprehensively evaluate the association between prolonged exposure to air pollution and the risk of HCC.
methodsWe searched PubMed, Scopus, and Embase databases. Eligible studies were selected based on predetermined inclusion criteria, and data were extracted independently by reviewers. Quality assessment was conducted using established tools, and statistical analysis was performed to calculate pooled hazard ratios (HRs), odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CI) using Review manager version 5.4.1.
resultsThe search yielded 21 studies comprising a total of 90,319,213 participants. Meta-analysis revealed statistically significant association between NO2 and PM2.5 exposure and HCC incidence with a pooled HR (HR: 1.14, 95% CI: 1.03–1.27, P value = 0.01) and (HR: 1.11, 95% CI: 1.02–1.20, P value = 0.01), respectively. Also, a statistically significant association between NO2 and PM2.5 exposure and HCC mortality revealed with a pooled HR (HR: 1.07, 95% CI: 1.03–1.12, P value = 0.002) and (HR: 1.17, 95% CI: 1.10–1.25, P value = 0.00001), respectively. PM10 and NOx did not show a significant association according to our review.
conclusionThis meta-analysis provides evidence of a potential link between air pollution and HCC risk, particularly with PM2.5 and NO2 exposure. However, further research is needed to elucidate the underlying mechanisms and establish causality. Addressing air pollution through collaborative efforts and environmental regulations may help mitigate the risk of HCC and other types of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.