Observational studyBMC gastroenterology2025
Epidemiology of acute pancreatitis: the influence of age and gender in a regional population.
Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Diagnostic Performance of the Uric Acid-To-Albumin Ratio in Predicting Severity of Acute Pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Article
- Validation of the ASALT Score for Predicting Biliary Etiology in Acute Pancreatitis: a Single-Center Study of 441 Patients.Maedica · 2026Article
- The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- Clinical utility of the lactate-to-albumin ratio for predicting mortality in elderly severe acute pancreatitis.Frontiers in medicine · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute pancreatitis (AP) is a common and potentially severe inflammatory condition of the pancreas with a heterogeneous etiology influenced by geographic, demographic, and lifestyle factors. This study aimed to evaluate the distribution of AP etiologies and their associations with age and sex in a regional cohort from a tertiary center. MATERIALS AND
methodsThis retrospective observational study included 445 adult patients hospitalized with a first episode of AP between January 2022 and October 2023. Data on demographics, etiology, severity (revised Atlanta classification), hospital course, and outcomes were extracted from medical records. Etiologies were classified as biliary, idiopathic, alcohol-related, drug-induced, hypertriglyceridemia (HTG), neoplasm-associated, or other miscellaneous causes. Age was grouped into five categories, and statistical analyses assessed the association between etiologies and demographic variables.
resultsThe median age was 65 years (range: 18-97), and 52.1% were female. Biliary etiology was the most frequent (66.1%), followed by idiopathic (9.4%), alcohol-related (7.0%), drug-induced (6.5%), neoplasm-associated (4.3%), and HTG-induced (3.1%). Females were significantly older than males (median 67 vs. 60 years, p < 0.001). Alcohol-related AP (AAP) was more common in males, particularly under age 55. Notably, among biliary AP (BAP) patients, males predominated in those under 55 (p = 0.02). Etiological patterns varied significantly by age. In patients aged ≥ 75 years, BAP was markedly more common (80.4% vs. 61.8%), whereas alcohol, drug, and HTG-related etiologies were rare. Severity of AP correlated with age and length of stay but not with etiology.
conclusionBiliary pancreatitis remains the predominant etiology in this region, especially among elderly patients. A novel finding of male predominance in younger BAP cases warrants further investigation. These data underscore the importance of regional age and sex specific approaches to AP prevention and management.
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