ArticleBMC medical imaging2025
Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Application of quantitative imaging parameters combined with tertiary lymphoid structures in recurrence risk assessment of soft tissue sarcoma: a retrospective study.Quantitative imaging in medicine and surgery · 2026Article
- Exploratory quantitative magnetic resonance imaging characterization of histopathologic subtype heterogeneity in osteosarcoma.Polish journal of radiology · 2026Article
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8 authors.
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Abstract
objectivesThe combination of dynamic-contrast-enhanced-magnetic-resonance-imaging (DCE-MRI) with the apparent-diffusion-coefficient (ADC) holds significant value for predicting tumor pathological outcomes. This study pioneers the combined application of DCE-MRI and ADC parameters to evaluate their utility in differentiating histopathological grades of adenoid cystic carcinoma (ACC).
methodsRetrospective diagnosis of 23 ear and temporal ACC patients was confirmed based on surgical pathology from March 2020 to April 2024. All patients underwent routine MRI, DWI, and DCE-MRI scans within one week before surgery. The lesion ADC values and DCE-MRI perfusion parameters, including Ve, Kep, Ktrans, and iAUC, were measured. Consistency tests were conducted on the measurements done by two physicians. The ADC values and DCE-MRI perfusion parameters between different pathological grades were compared. The correlation among all parameters and ACC pathological grading were analyzed, and the diagnostic accuracy of each parameter was assessed using receiver-operating-characteristic (ROC) curves.
resultsThe measurements from the two observers showed high consistency (ICC > 0.9). Ktrans, iAUC, and ADC values demonstrated significant differences between different pathological grades (P < .01, P < .05, P < .05). Correlation analysis indicated that Ktrans, Kep, Ve, and iAUC were positively correlated with ACC pathological grading, and Ktrans demonstrated the most robust correlation (correlation coefficient r = .578, P < .01). In contrast, ADC values were markedly and negatively correlated with pathological grading (r=-.470, P < .05). In ROC analysis, the area-under-the-curve (AUC) for Ktrans, iAUC, and ADC were 0.841, 0.790, and 0.778, respectively, all higher than those for Kep and Ve. Ktrans showed the best diagnostic performance.
conclusionCombining DCE-MRI perfusion parameters with ADC values provides a non-invasive and effective method for preoperative grading of ACC, with Ktrans, iAUC, and ADC showing strong diagnostic potential. These findings support more accurate tumor characterization and personalized treatment planning, warranting further validation in larger prospective studies. CLINICAL TRIAL NUMBER: Not applicable.
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