Evidence map›Paper›PMID 40885886›Full record

ArticleMolecular diversity2026

Mechanistic basis of N-terminal domain-mediated allostery in SIRT6: integrating molecular dynamics simulations and biochemical assays.

Haiyue Tang, Wenjie Ma, Guoyou Zhang, Jiacheng Wei, Jianyang Ao, Shaoyong Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Assessing the Performance of BioEmu in Understanding Protein Dynamics.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haiyue Tang *Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Wenjie Ma *Department of Emergency, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Guoyou ZhangDepartment of Spine Surgery, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Jiacheng WeiDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jianyang AoDepartment of Hepatobiliary and Pancreatic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. aojysili@126.com.
Shaoyong LuKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China. lushaoyong@sjtu.edu.cn.

Funding

National Key R&D Program of China 2023YFC3404700
6 · The paper itself

Abstract

SIRT6, a pivotal member of the NAD

Indexed as

Molecular Dynamics SimulationSirtuinsAcetylationAllosteric RegulationHumansLysineNADProtein BindingProtein DomainsLysineNADSIRT6 protein, humanSirtuinsAllosteric regulationCommunity network analysisEnzyme catalysisMolecular dynamics simulationsSIRT6

Identifiers

PMID40885886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.