Evidence map›Paper›PMID 40885875›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025

Integrated profiling of essential metals, phenolic compounds, anti-inflammatory and hydroxyl radical scavenging activities for five medicinal plants.

Biljana Kukavica, Siniša Škondrić, Kristina Knežević, Toda Ignjatović, Dijana Mihajlović, Đura Nakarada, Nataša Lukić, Miloš Mojović

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Biljana KukavicaFaculty of Natural Sciences and Mathematics, University of Banja Luka, Mladena Stojanovića 2, 78000, Banja Luka, Bosnia and Herzegovina. biljana.kukavica@pmf.unibl.org.ORCID http://orcid.org/0000-0003-1530-0391
Siniša ŠkondrićFaculty of Natural Sciences and Mathematics, University of Banja Luka, Mladena Stojanovića 2, 78000, Banja Luka, Bosnia and Herzegovina.ORCID http://orcid.org/0000-0002-6760-2976
Kristina KneževićFaculty of Natural Sciences and Mathematics, University of Banja Luka, Mladena Stojanovića 2, 78000, Banja Luka, Bosnia and Herzegovina.
Toda IgnjatovićFaculty of Natural Sciences and Mathematics, University of Banja Luka, Mladena Stojanovića 2, 78000, Banja Luka, Bosnia and Herzegovina.
Dijana MihajlovićFaculty of Agriculture, University of Banja Luka, University City, Vojvode Petra Bojovića Blvd. 1A, 78000, Banja Luka, Bosnia and Herzegovina.ORCID http://orcid.org/0000-0002-1207-1776
Đura NakaradaFaculty of Physical Chemistry, University of Belgrade, Studentski Trg 12-16, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-0154-6430
Nataša LukićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, Belgrade, 152, 11042, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-4363-5212
Miloš MojovićFaculty of Physical Chemistry, University of Belgrade, Studentski Trg 12-16, 11000, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-1868-9913

Funding

Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-136/2025-03/200146Ministry of Scientific and Technological Development and Higher Education of the Republic of Srpska 19.032/961-951/23
6 · The paper itself

Abstract

Medicinal plants are valuable sources of bioactive compounds. In this study, we analyzed the levels of essential metals (Fe, Cu, Zn, Mn) in the leaves of Punica granatum, Teucrium montanum, Chaerophyllum coloratum, Petteria ramentacea, and Menyanthes trifoliata using atomic absorption spectrophotometry. Ethanolic leaf extracts were assessed for anti-inflammatory activity via bovine serum albumin BSA and egg albumin (EgA) denaturation assays and for antioxidant potential by hydroxyl radical scavenging using EPR (Electron Paramagnetic Resonance) spectroscopy. Metal concentrations varied across species: Fe (33-93 mg/kg), Cu (4.29-11.61 mg/kg), Zn (12.39-105 mg/kg), and Mn (1.38-1005 mg/kg), with T. montanum showing the highest Fe and M. trifoliata with highest Cu, Zn and Mn levels. Total phenolic content (TPC) ranged from 32 to 117 mg/g

Indexed as

Anti-Inflammatory AgentsFree Radical ScavengersHydroxyl RadicalPhenolsPlant ExtractsPlants, MedicinalAnimalsAntioxidantsCattleMicePlant LeavesSerum Albumin, BovineAnti-Inflammatory AgentsAntioxidantsFree Radical ScavengersHydroxyl RadicalPhenolsPlant ExtractsSerum Albumin, BovineAntioxidative activityMicronutrientsOxidative stressPhenolic compoundsProtein denaturation

Identifiers

PMID40885875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.