Evidence map›Paper›PMID 40885848›Full record

ReviewMolecular psychiatry2026

The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.

Layla Banihashemi, Yicheng Zhang, Alison E Hipwell, Mary L Phillips

Abstract readReview
In one paragraph

Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Layla Banihashemi *Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. Layla.banihashemi@pitt.edu.ORCID http://orcid.org/0000-0001-6317-0494
Yicheng Zhang *Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID http://orcid.org/0000-0002-6982-6471
Alison E HipwellDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID http://orcid.org/0000-0001-7179-1151
Mary L PhillipsDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID http://orcid.org/0000-0003-4958-1291

Funding

Caregiving effects on the early development of infant brain-behavior relationshipsR01MH115466 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HIPWELL, ALISON E, PHILLIPS, MARY LOUISE · 2018 to 2022
$3.6M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NIH HHS S10 OD028483NIMH NIH HHS R01 MH115466U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD028483U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH115466
6 · The paper itself

Abstract

Infancy marks a critical period of developing brain-behavior relationships that might influence the emergence of emotional and behavioral problems and psychopathology later in childhood and adolescence. In this review, we describe infant MRI studies that examined the development of neural networks, their associations with emerging emotional reactivity and regulation, and the relationships of caregiver factors, such as psychopathology, parenting behaviors and socioeconomic status (SES), with these developmental trajectories. We highlight the potential of utilizing infant MRI methodologies to identify key neural network structural and functional substrates of current and future emotional reactivity and regulation. Such an approach could identify early objective neural markers of dysregulation problems that are precursors of emotional and behavioral disorders, help monitor the effectiveness of existing interventions, and ultimately guide the development of new interventions for at-risk infants.

Indexed as

EmotionsMagnetic Resonance ImagingMental DisordersNerve NetBrainChild DevelopmentHumansInfant

Identifiers

PMID40885848
PMCPMC12700804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.