ArticleBiological trace element research2026
Zinc Attenuates Cadmium and High-Fat Diet-Induced Cardiomyopathy by Enhancing Metallothionein-Mediated Cardiac Protection.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Zinc Supplementation Sustains Diaphragm Contractility and PreservesBiomolecules · 2026Article
- Cellular and molecular dysregulation of the esophageal epithelium in systemic sclerosis.JCI insight · 2026Article
- The Protective Effect of Zinc Supplementation Against Oxidative Stress and Oxidative Modifications of Cellular Macromolecules in the Mandibular Bone of Rats Exposed to Cadmium.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
With the worsening of environmental pollution and the rising prevalence of obesity, the combined effects of cadmium (Cd) exposure and obesity-related metabolic disorders contribute to cardiovascular injury. Therefore, it is urgent to explore their molecular mechanisms and prevention strategies. This study focused on the protective effects and mechanisms of zinc (Zn) supplementation on cardiac function in obese individuals with Cd toxicity. In present study, we established a cardiomyopathy model with dual pathological burdens of heavy Cd exposure and high fat diet induced obesity. Our results showed that Zn supplementation improved the insulin sensitivity and myocardial function. Moreover, Zn increased metallothionein levels which facilitated heavy metal chelation, reduced the harmful effects of Cd, and alleviated myocardial oxidative stress, hypertrophy, fibrosis, and apoptosis in the Cd toxicity and obesity related cardiomyopathy. These findings provide a theoretical foundation for developing nutritional intervention strategies for patients affected by environmental pollution and metabolic syndrome, while promoting the precise application of functional health products.
Indexed as
Identifiers
40885794What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.