Evidence map›Paper›PMID 40885782›Full record

ArticleNPJ Regenerative medicine2025

Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing.

Mahmoud Farahat, Sophie Brosset, Yufei Chen, Ayesha Aijaz, Graham Rix, Bhavishya Challagundla, Margarita Elloso, Maria Fernanda Hutter, Ian M Rogers, Marc G Jeschke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Porcine Wound Models: The Gold Standard for Translational Research in Cutaneous Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahmoud Farahat *Department of Surgery, McMaster University, Hamilton, ON, Canada.
Sophie Brosset *Sunnybrook Research Institute, Toronto, ON, Canada.
Yufei ChenDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Ayesha AijazDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Graham RixCentre for Burn Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Bhavishya ChallagundlaCentre for Burn Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Margarita EllosoDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Maria Fernanda HutterDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Ian M RogersDivision of Reproductive Sciences, Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital and The University of Toronto, Toronto, ON, Canada.
Marc G JeschkeDepartment of Surgery, McMaster University, Hamilton, ON, Canada. marc.jeschke@hhsc.ca.

Funding

Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
Canada Foundation for Innovation 25407CIHR 123336NIGMS NIH HHS R01 GM087285NIH HHS 2R01GM087285-05A1
6 · The paper itself

Abstract

The key to surviving severe burns is rapid burn wound excision and closure, yet extensive wounds often surpass natural healing capacity. Alternative treatments, such as synthetic skin substitutes, have not emerged as a standard, optimal solution. Stem cell therapies, especially using allogenic sources, show promise in enhancing wound repair. Induced mesenchymal stem cells (iMSCs) have demonstrated vast possibilities to overcome traditional stem cell therapy limitations. This study utilized Cord tissue-derived iMSCs (CT-iMSCs) incorporated into well-established epidermal-dermal substitutes Integra® Dermal Regeneration Template (DRT) at 5000-20,000 cells/cm

Identifiers

PMID40885782
PMCPMC12398485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.