Evidence map›Paper›PMID 40885754›Full record

ArticleNature communications2025

Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.

Shunyi Lu, Jie Cao, Zhuorun Song, Fei Gong, Peng Yang, Jun Ge, Yunfei He, Zhihui Han, Guanghui Hou, Zimin Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shunyi Lu *Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.ORCID http://orcid.org/0009-0007-8045-5855
Jie Cao *Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Zhuorun Song *Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Fei Gong *Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Peng YangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Jun GeDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Yunfei HeThe First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Zhihui HanInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Guanghui HouInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Zimin ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Yuqi YangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Yun TengDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Zengli ZhangDepartment of Environmental Health School of Public Health, Soochow University, Suzhou, 215123, China.
Jun ZouDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China. jzou@suda.edu.cn.ORCID http://orcid.org/0000-0003-0443-3156
Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China. lcheng2@suda.edu.cn.ORCID http://orcid.org/0000-0001-5324-9094
Huilin YangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China. suzhouspine@163.com.ORCID http://orcid.org/0000-0002-9459-7981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of osteoporosis and related bone defects remains challenging. This study identifies pyroptosis-driven inflammation as a key disruptor of bone homeostasis. To address this, we develop a magnesium-gelatin composite microsphere scaffold (GelMa/Mg/DMF MS) that exploit pyroptosis blockade and hydrogen-mediated inflammation regulation for osteoporosis treatment. This porous microsphere scaffold is implanted into bone defects to achieve the sustained release of hydrogen gas, magnesium ions (Mg

Indexed as

MicrospheresOsteoporosisPyroptosisAnimalsCellular MicroenvironmentDisease Models, AnimalFemaleGelatinHumansHydrogenInflammationMagnesiumMiceMice, Inbred C57BLOsteoblastsTissue ScaffoldsGelatinHydrogenMagnesium

Identifiers

PMID40885754
PMCPMC12398577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.