Evidence map›Paper›PMID 40885707›Full record

ArticleTranslational psychiatry2025

Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in mice.

Na-Yun Lyu, Guo-Guang Xie, Zhi-Wen Hu, Tian-Jie Lyu, Rui Qin, Lu Chen, Yun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Na-Yun Lyu *Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.ORCID http://orcid.org/0000-0001-6554-2036
Guo-Guang Xie *Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Zhi-Wen Hu *Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Tian-Jie LyuDepartment of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Rui QinDepartment of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Lu ChenDepartment of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Yun WangDepartment of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education of China and National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. wangy66@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-4357-8166

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0203204National Natural Science Foundation of China (National Science Foundation of China) 32030052
6 · The paper itself

Abstract

Fear memory is crucial for animals to effectively respond to dynamic environments and survive dangerous stimuli. However, aberrant fear memory contributes to various psychiatric disorders, such as post-traumatic stress disorder (PTSD). Despite its importance, the precise molecular mechanisms underlying fear memory remain insufficiently understood. In this study, we highlight the pivotal role of the epigenetic factor chromodomain Y-like protein (CDYL) in the regulation of fear memory. We discovered that ablation of CDYL in CaMKIIα

Indexed as

Cyclin-Dependent Kinase 5FearMemoryAnimalsHippocampusMaleMiceMice, Inbred C57BLPhosphorylationTripartite Motif ProteinsUbiquitin-Protein LigasesCdk5 protein, mouseCyclin-Dependent Kinase 5Tripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40885707
PMCPMC12398608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.