Evidence map›Paper›PMID 40885612›Full record

ReviewTrends in cancer2025

Polo-like kinases as immune modulators: a new frontier in cancer immunotherapy.

Tanya Jaiswal, Gagan Chhabra, Nihal Ahmad

Abstract readReview
In one paragraph

Review in Trends in cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tanya JaiswalDepartment of Dermatology, University of Wisconsin, Madison, WI 53705, USA.
Gagan ChhabraDepartment of Dermatology, University of Wisconsin, Madison, WI 53705, USA.
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, 53705, USA. Electronic address: nahmad@dermatology.wisc.edu.

Funding

Functional and Therapeutic Significance of PLK4 in MelanomaR01CA261937 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Nihal Ahmad · 2022 to 2026
$2.9M
BLRD VA I01 BX005917BLRD VA IK6 BX006041CSRD VA I01 CX002210NCI NIH HHS R01 CA261937
6 · The paper itself

Abstract

Cancer immunotherapy has transformed treatment but faces challenges such as immune evasion and toxicity. Polo-like kinases (PLKs), frequently dysregulated in tumors, are emerging as key immune modulators. Combining PLK inhibition with immunotherapy may overcome resistance, enhance antitumor responses, and improve clinical outcomes, offering an optimally efficient strategy for cancer treatment.

Indexed as

Cell Cycle ProteinsImmune Checkpoint InhibitorsImmunotherapyNeoplasmsProtein Serine-Threonine KinasesProto-Oncogene ProteinsAnimalsDrug Resistance, NeoplasmHumansPolo-Like Kinase 1Polo-like KinasesProtein Kinase InhibitorsCell Cycle ProteinsImmune Checkpoint InhibitorsPolo-Like Kinase 1Polo-like KinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsFASIFNPD-L1PLKTGF-β

Identifiers

PMID40885612
PMCPMC12403973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.