ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026
High-Resolution Manometry in Treated Achalasia: Scoping Review and Novel Nomenclature.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Role of Functional Lumen Imaging Probe (FLIP) in Addition to High-Resolution Manometry and Timed Barium Esophagram in Treated Achalasia Patients With Persistent or Recurrent Symptoms.Neurogastroenterology and motility · 2026Observational
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12 authors.
Funding
Abstract
BACKGROUND &
aimsChicago Classification (CC) for high-resolution manometry (HRM) is the standard for diagnostic criteria of primary motility disorders, achalasia being the most relevant. CC does not include recommendations on HRM in treated achalasia, either after surgery or endoscopic interventions.
methodsAfter systematic review of literature on 3 major databases (Pubmed/MEDLINE, Embase, Web of Science) from inception to December 2024, a group of 12 esophageal motility experts provided recommendations for HRM interpretation in treated achalasia and proposed novel nomenclature and management flowchart to address gaps in diagnostic CC hierarchy.
resultsThe search yielded 40 articles on HRM in treated achalasia. Unsuccessful achalasia treatment results in high-integrated relaxation pressure (IRP) and obstructive features especially on provocative maneuvers. We propose the term treated achalasia with outflow obstruction (TAOO) instead of achalasia. Conversely, the term adequately treated achalasia (ATA) is suggested in the absence of obstructive features, instead of absent contractility or ineffective motility, which could be misleading. We propose an IRP cutoff of the upper limit of normal according HRM system utilized, similar to that recommended for the naïve sphincter by CC to describe incomplete sphincter relaxation despite treatment. Intrabolus pressurization and abnormal IRP on rapid drink challenge (RDC) are additional obstructive features. Assessment of body contractility, either ineffective (<450 mm Hg cm s) or spastic (<4.5 sec), is relevant to disease profiling. HRM combined with impedance represents a valuable tool to assess esophageal emptying.
conclusionsThis scoping review with expert recommendations provides guidance for HRM interpretation in treated achalasia and introduces novel descriptive terms to describe pathophysiology following achalasia treatment. Conventional CC should not be used in treated achalasia description.
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