SynthesisAdvances in nutrition (Bethesda, Md.)2025
Dietary Polyunsaturated to Saturated Fatty Acid Ratio as an Indicator for LDL Cholesterol Response: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Synthesis in Advances in nutrition (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- The Effect of a Low-Energy and Low-Glycemic Diet on Adipose Tissue Metabolism and Energy Expenditure in Women with Excess Body Weight.Nutrients · 2025Trial
- Tissue-Specific Lipid Profiles and Valorization Potential of Oils from Processing By-Products of the Invasive Blackchin Tilapia (Foods (Basel, Switzerland) · 2026Article
- Comprehensive Analysis of Phytochemical Compounds in Seeds of Indigenous Grape Varieties Cultivated in Southeastern Anatolia: Fatty Acids, Tocopherols, Phytosterols, Vitamins, and Antioxidant Properties.Molecules (Basel, Switzerland) · 2026Article
- Chemical and Functional Characterization of a Novel European Black Soybean Variety.Molecules (Basel, Switzerland) · 2026Article
- Comparative Characterization of Ancient Wheat Cultivars Through Fatty Acid and Phytosterol Profiling.Foods (Basel, Switzerland) · 2026Article
- One Diet Does Not Fit All: A Systematic Review and Meta-Analysis of Gene-Diet Interactions Affecting Blood Lipid Profiles.Current issues in molecular biology · 2026Review
- Diet Quality, Physical Activity, and Epigenetic Aging in the Finnish Working-Age Population.The Journal of nutrition · 2026Article
- Bromatological Profile of Fruits fromAntioxidants (Basel, Switzerland) · 2026Article
- Improving Meat Quality and Lipid Metabolism of Finishing Pigs by Replacing Dietary Soybean Meal with Enzyme-Bacteria Co-Fermented Rapeseed Meal.Foods (Basel, Switzerland) · 2026Article
- Dietary supplementation with organic choline improves layer performance, egg production, and egg quality.Journal of animal science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary guidelines recommend limiting saturated fatty acid (SFA) intake by replacing SFA with polyunsaturated fatty acid (PUFA). PUFA and SFA have opposing effects on low density lipoprotein (LDL) cholesterol, and therefore, the dietary ratio of PUFA to SFA (P:S) may be a better indicator of LDL cholesterol response than SFA alone.
objectivesA systematic review and meta-analysis of randomized clinical trials was conducted to examine LDL cholesterol responses to higher P:S ratio diets compared with isoenergetic, total fat-matched diets with lower P:S ratios in healthy adults.
methodsA systematic search of PubMed, Cochrane Central, and Web of Science was conducted. Randomized complete feeding trials lasting ≥3 wk, including 2 test diets with P:S ratios differing by >0.3 that were matched for energy, fiber, and total fat, were included. Random effects meta-analysis was used to evaluate the mean difference (MD) in LDL cholesterol with higher P:S ratio diets compared to lower P:S ratio diets. Heterogeneity in the effect of the P:S ratio by SFA content of the test diets was also evaluated.
resultsIn total, 1001 publications were identified, and 24 publications reporting 24 trials (n = 1011) were eligible. Higher P:S ratio diets (median P:S ratio 1.2; PUFA 10.6% kcal; SFA 8.0% kcal; and MUFA 12.6% kcal) lowered LDL cholesterol [MD -9.83 mg/dL; 95% confidence interval (CI): -13.63, -6.04; I
conclusionsCompared with lower P:S ratio diets, higher P:S ratio diets were associated with greater LDL cholesterol reductions in generally healthy adults, and this effect was stronger when PUFA replaced SFA. This trial was registered at Prospective Register of Systematic Reviews (PROSPERO) as CRD42023452550.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.