Stress reactivity is modulated by cannabinoid type-1 receptors in norepinephrine and epinephrine neurons in a context-dependent manner.

Christopher B Engborg, Manaswini Pujar, Rahul N Kanadia, Natale R Sciolino

Abstract read

In one paragraph

Article in Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher B EngborgDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.

Manaswini PujarDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.

Rahul N KanadiaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA; Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.

Natale R SciolinoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA; Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; Department of Psychological Sciences, University of Connecticut, Storrs, CT 06269, USA; Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address: natale.sciolino@uconn.edu.

Funding

Defining locus coeruleus-norepinephrine (LC-NE) circuits in feedingR00DK119586 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI SCIOLINO, NATALE R · 2021 to 2023

$730k

NIDDK NIH HHS R00 DK119586

6 · The paper itself

Abstract

Disruptions in the endocannabinoid system (ECS) and norepinephrine/epinephrine (NE/E) system are individually linked to stress-related neuropsychiatric disorders, but their interaction in shaping stress responses remains unclear. We investigated the role of the ECS's primary receptor, cannabinoid type-1 receptor (CB1R), in NE/E-producing neurons using anatomical, behavioral, and physiological analyses in a conditional knockout mouse model (Cnr1

Indexed as

Adrenergic NeuronsEpinephrineNeuronsNorepinephrineReceptor, Cannabinoid, CB1Stress, PsychologicalAnimalsAnxietyLocus CoeruleusMaleMiceMice, Inbred C57BLMice, KnockoutRestraint, PhysicalCNR1 protein, mouseEpinephrineNorepinephrineReceptor, Cannabinoid, CB1AnxietyCannabinoidCatecholamineFearKnockout mouseStress

Identifiers

PMID40885375

DOI10.1016/j.neuroscience.2025.08.046

PMCPMC12421906

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.