Evidence map›Paper›PMID 40885290›Full record

ArticleThe Journal of allergy and clinical immunology2025

Impact of race-based spirometry equations on guideline-based asthma management in clinical trials.

Cynthia M Visness, Christine A Sorkness, Ronald Sorkness, Peter J Gergen, Michael Nodzenski, Daniel J Jackson, National Institute of Allergy and Infectious Diseases–sponsored Childhood Asthma in Urban Settings Network

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cynthia M VisnessRho Inc, Durham, NC. Electronic address: cindy_visness@rhoworld.com.
Christine A SorknessUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Ronald SorknessUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Peter J GergenNational Institute of Allergy and Infectious Diseases, Rockville, Md.
Michael NodzenskiRho Inc, Durham, NC.
Daniel J JacksonUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
National Institute of Allergy and Infectious Diseases–sponsored Childhood Asthma in Urban Settings Network

Funding

Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1M
Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Childhood Asthma in Urban Settings Leadership Center Administrative Supplement for URECA Yr4UM1AI160040 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2021 to 2026
$41.1M
RhoFED AA-SCCCU01AI178772 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI Gloria David, Cynthia M Visness · 2023 to 2026
$37.2M
Inner-City Asthma Consortium-266025496-266025496N01AI025496 · NIAID · UNIVERSITY OF WISCONSIN · PI BUSSE, WILLIAM · 2002 to 2006
–
NIAID NIH HHS HHSN272200900052CNIAID NIH HHS HHSN272201000052INIAID NIH HHS N01 AI025482NIAID NIH HHS N01 AI025496NIAID NIH HHS U01 AI178772NIAID NIH HHS UM1 AI114271NIAID NIH HHS UM1 AI160040NIAID NIH HHS UM2 AI117870
6 · The paper itself

Abstract

backgroundThe American Thoracic Society recently recommended that race- and ethnicity-specific equations for spirometry be replaced with race-neutral equations. This change could have implications for asthma management.

objectiveOur aim was to examine the effect of race-specific versus race-neutral spirometry reference equations on the resultant guideline-directed asthma therapy in a study population with a high proportion of Black children.

methodsWe pooled and harmonized data on 2076 children and adolescents across 4 Inner-City Asthma Consortium studies that had all used a computer-asssisted algorithm for management of asthma medication. The asthma control level was recalculated, first by using the percent predicted FEV

resultsAmong urban Black children not already at the highest recommended inhaled corticosteroid doses, 18% would have been assigned a higher medication step at study entry when using the race-neutral rather than race-specific reference equations to assess asthma control. A very small number of children in other race or ethnicity groups had a recommendation for a higher medication step.

conclusionThe transition to use of race-neutral values for measures of lung function has the potential to reduce racial bias in diagnosing and treating asthma.

Indexed as

AsthmaSpirometryAdolescentAdrenal Cortex HormonesAnti-Asthmatic AgentsBlack or African AmericanChildClinical Trials as TopicFemaleHispanic or LatinoHumansMalePractice Guidelines as TopicAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaBlackracereference equationsspirometry

Identifiers

PMID40885290
PMCPMC12412980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.