Evidence map›Paper›PMID 40885187›Full record

ArticleCell host & microbe2025

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.

Kevin D Eislmayr, Charlotte A Nichols, Fitty L Liu, Sudyut Yuvaraj, Janet Peace Babirye, Justin L Roncaioli, Jenna Vickery, Gregory M Barton, Cammie F Lesser, Russell E Vance

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kevin D EislmayrDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Charlotte A NicholsDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Fitty L LiuDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Sudyut YuvarajDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Janet Peace BabiryeDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Justin L RoncaioliDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Jenna VickeryDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Gregory M BartonDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.
Cammie F LesserDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, USA; Tufts Stuart B Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University, Boston, USA.
Russell E VanceDivision of Immunology & Molecular Medicine, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Center for Emerging and Neglected Diseases, University of California, Berkeley, Berkeley, CA, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: rvance@berkeley.edu.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
The cell biology of Toll-like receptor 9: a mechanism to prevent autoimmunityR01AI072429 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton · 2008 to 2026
$7.6M
Functional and Structural Dissection of Inflammasome ActivationR37AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUSSELL E VANCE · 2018 to 2026
$3.8M
Specificity and in vivo function of the Naip/Nlrc4 inflammasomesR01AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2008 to 2017
$3.6M
Shigella mediated regulation of epithelial cell inflammasomesR01AI169795 · NIAID · TUFTS UNIVERSITY BOSTON · PI CAMMIE LESSER · 2023 to 2026
$3.0M
Dissection of Shigella pathogenesis in vivo using a new oral infection mouse modelR01AI155634 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2020 to 2024
$2.2M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI072429NIAID NIH HHS R01 AI075039NIAID NIH HHS R01 AI155634NIAID NIH HHS R01 AI169795NIAID NIH HHS R37 AI075039NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Bacteria of the genus Shigella replicate in intestinal epithelial cells and cause shigellosis, a severe diarrheal disease that resolves spontaneously in most healthy individuals. During shigellosis, neutrophils are abundantly recruited to the gut and have long been thought to be central to Shigella control and pathogenesis. However, how shigellosis resolves remains poorly understood due to the longstanding lack of a tractable and physiological animal model. Here, using our newly developed Nlrc4

Indexed as

Dysentery, BacillaryEpithelial CellsInterferon-gammaInterleukin-12Intestinal MucosaMacrophagesShigellaToll-Like ReceptorsAnimalsDisease Models, AnimalImmunity, InnateIntestinesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsInterferon-gammaInterleukin-12Toll-Like ReceptorsIFN-gIL-12innate immunityintestinal epithelial cellsmacrophagesmouse modelneutrophilsShigellaShigellosis

Identifiers

PMID40885187
PMCPMC12471108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.