ArticleThe Journal of international medical research2025
Exploring optimal serum selenium range for heart failure prevention: A U-shaped association and mediation by hepatic steatosis in US adults.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveThe relationship between serum selenium levels and heart failure risk remains unclear. This study aimed to investigate the potential nonlinear association between serum selenium level and heart failure risk and explore whether hepatic steatosis and dyslipidemia mediate this relationship.MethodsData from 6969 adults in the National Health and Nutrition Examination Survey 2017-2020 cohort were analyzed. Logistic regression, restricted cubic spline, and random forest models were used to assess associations between serum selenium level and heart failure risk. Mediation analysis was used to evaluate the indirect effects of hepatic steatosis and lipid parameters. Mendelian randomization was used to infer causality.ResultsA U-shaped association was identified between serum selenium level and heart failure risk (
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