Evidence map›Paper›PMID 40884761›Full record

ArticleFuture medicinal chemistry2025

Piperonal-derived Schiff base molecules as potential multi-target therapeutic agents against Alzheimer's and diabetes.

Asif Ahmad, Uzma Salar, Musa Özil, Nimet Baltaş, Syeda Sumayya Tariq, Zaheer Ul-Haq, Khalid Mohammed Khan, Farzana Shaheen

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Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Asif AhmadThird World Center for Science and Technology, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Uzma SalarDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.ORCID 0000-0003-1871-9112
Musa ÖzilDepartment of Chemistry, Recep Tayyip Erdogan University, Rize, Turkey.
Nimet BaltaşDepartment of Chemistry, Recep Tayyip Erdogan University, Rize, Turkey.ORCID 0000-0003-4748-0665
Syeda Sumayya TariqDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Zaheer Ul-HaqDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.ORCID 0000-0002-8530-8711
Khalid Mohammed KhanH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.ORCID 0000-0001-8337-4021
Farzana ShaheenThird World Center for Science and Technology, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe dual burden of diabetes and Alzheimer's highlights the urgent need for multifunctional therapeutic agents. This study explores piperonal-derived Schiff base derivatives as potential dual-action enzyme inhibitors against

methodsSchiff base derivatives of piperonal (heliotropin) were synthesized, structurally characterized, and explored against established drug targets of diabetes mellitus (DM) and Alzheimer's disease (AD).

resultsCompounds

conclusionThese complementary studies highlight several hit candidates for further development as therapeutic agents against DM and AD.

Indexed as

Alzheimer DiseaseBenzodioxolesDiabetes MellitusHypoglycemic AgentsAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesButyrylcholinesteraseCholinesterase InhibitorsGlycoside Hydrolase InhibitorsHumansMolecular Docking SimulationMolecular StructureSchiff BasesStructure-Activity RelationshipAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesBenzodioxolesButyrylcholinesteraseCholinesterase InhibitorsGlycoside Hydrolase InhibitorsHypoglycemic AgentsSchiff Basesacarboseanti-AlzheimerantidiabeticantioxidantdonepezilPiperonal-derived Schiff bases

Identifiers

PMID40884761
PMCPMC12408053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.