Evidence map›Paper›PMID 40884690›Full record

SynthesisApplied health economics and health policy2026

The Economics of Antibiotic Resistance: A Systematic Review and Meta-analysis Based on Global Research.

Sabela Siaba, Bruno Casal, Iván López-Martínez

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Applied health economics and health policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sabela SiabaDepartment of Economics, Faculty of Economics and Business, Universidade da Coruña, Campus de Elviña, 15008, A Coruña, Spain. sabela.siabac@udc.es.
Bruno CasalDepartment of Economics, Faculty of Economics and Business, Universidade da Coruña, Campus de Elviña, 15008, A Coruña, Spain.
Iván López-MartínezDepartment of Economics, Faculty of Economics and Business, Universidade da Coruña, Campus de Elviña, 15008, A Coruña, Spain.

Funding

Ministerio de Ciencia, Innovación y Universidades PID2021-127898OB-I00Ministerio de Universidades FPU Grant
6 · The paper itself

Abstract

backgroundAntibiotic resistance (ABR) is a growing global health threat; reliable evidence on its impact is crucial for prioritising public health interventions.

objectiveThis study provides an updated, systematic review and meta-analysis to determine the true effect size of resistant infections on economic and clinical outcomes. It also evaluates methodologies used in ABR economic literature, offering recommendations for improving future research.

methodsFollowing PRISMA guidelines, 11,252 articles published between 2000 and 2022 were reviewed from several databases. Studies were included if they reported the economic costs of ABR in humans and compared resistant with susceptible infections. Meta-analyses were conducted using random intercept models; standardised mean difference (SMD) was used for length of stay, and odds ratio (OR) for mortality. The Mantel-Haenszel method was applied to obtain pooled estimates.

resultsResults showed that 73% of the studies were conducted in high-income economies, the majority were performed at tertiary care settings (71%) and 67% employed only a hospital perspective. The available evidence indicated that the attributable cost of resistant infections ranged from EUR

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, MicrobialGlobal HealthHumansLength of StayAnti-Bacterial Agents

Identifiers

PMID40884690
PMCPMC12790539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.