Evidence map›Paper›PMID 40884660›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

DNA Damage, Telomere and Centromere Dysfunction in Chromothripsis Rearrangements.

Radhia M'kacher, Bruno Colicchio, Steffen Junker, Simon Schabat, Raja Belaiba, Louis Sontos, Leonhard Heidingsfelder, Wala Najar, Andreas Plesch, Philippe Voisin and 3 more

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Radhia M'kacherCell Environment, Evry, France. radhia.mkacher@cell-environment.com.
Bruno ColicchioIRIMAS, Institut de Recherche en Informatique, Mathématiques, Automatique et Signal, Université de Haute-Alsace, Mulhouse, France.
Steffen JunkerInstitute of Biomedicine, University of Aarhus, Aarhus, Denmark.
Simon SchabatCell Environment, Evry, France.
Raja BelaibaCell Environment, Evry, France.
Louis SontosCell Environment, Evry, France.
Leonhard HeidingsfelderMetaSystems GmbH, Altlussheim, Germany.
Wala NajarCell Environment, Evry, France.
Andreas PleschMetaSystems GmbH, Altlussheim, Germany.
Philippe VoisinCell Environment, Evry, France.
Alain DieterlenIRIMAS, Institut de Recherche en Informatique, Mathématiques, Automatique et Signal, Université de Haute-Alsace, Mulhouse, France.
Eric JeandidierService de Génétique, Groupe Hospitalier de la Région de Mulhouse et Sud Alsace Mulhouse, Mulhouse, France.
Patrice CardeDepartment of Hematology, Gustave Roussy Cancer Campus, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The analysis of the origin of chromothripsis, catastrophic chromosomal rearrangements, has provided exceptional insights into various aspects of tumor progression and genetic disorders. Findings in chromothripsis have not only enhanced our understanding of genomic instability mechanisms, but also reshaped our views on chromosome mechanics. To date, the major mechanisms of chromothripsis described involve the incorporation of micronuclei into the primary nucleus and telomere crisis through the formation of dicentric chromosomes. Here, we reevaluated the impact of telomere and centromere sequences in the formation of micronuclei and anaphase bridges in cancer patients using our high throughput technique for the detection of telomere and centromere dysfunction and chromosomal instability biomarkers. We also discuss the emerging potential of exploiting telomere and centromere dysfunction combined with DNA damage as prognostic biomarkers and tools for personalized patient management.

Indexed as

CentromereChromothripsisDNA DamageTelomereChromosomal InstabilityGenomic InstabilityHumansNeoplasmsAnaphase bridgeCentromereChromosomal instabilityChromothripsisMicronucleiTelomere

Identifiers

PMID40884660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.