ArticlePediatric surgery international2025
Dosage and duration of ursodeoxycholic acid therapy Post-Kasai portoenterostomy in biliary atresia: a multicenter cross-sectional study with age stratification.
Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cholestasis-reducing effects of bezafibrate on survivors of biliary atresia with native livers: A prospective phase II trial.Hepatology communications · 2026Trial
- Association between post-Kasai cholangitis episodes, ursodeoxycholic acid regimen, and portal hypertension risk in biliary atresia: a multicenter cross-sectional study.Pediatric surgery international · 2026Article
- Beyond age thresholds: towards multidimensional prognostic strategies in Kasai portoenterostomy.Pediatric surgery international · 2026Article
- Biliary Atresia: advances and challenges in early diagnosis and management.Jornal de pediatriaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
purposeEvaluate clinical efficacy of ursodeoxycholic acid (UDCA) in biliary atresia (BA) infants post-Kasai portoenterostomy (KPE) using real-world data.
methodsRetrospective analysis of 698 BA patients from eight Chinese pediatric centers (2020-2025). Age-stratified analyses used propensity score matching (PSM) and inverse probability treatment weighting (IPTW) to adjust baseline differences. Primary outcomes were UDCA utilization and effects on bilirubin (TBil, DBil) and total bile acid (TBA) levels.
resultsThe median follow-up duration for the cohort was 49 months (IQR: 25-74), with male patients accounting for 54.2% (379/698). The median age at surgery was 59 days (IQR: 46-75). A history of cholangitis was present in 53.1% of patients (371 cases), and 63.5% (443 cases) underwent open Kasai portoenterostomy. After PSM/IPTW adjustment, UDCA within 12 months significantly reduced TBil, DBil, and TBA. Initiation before 12 months reduced TBil-elevated (TBil > 20 μmol/L) odds by 80% (OR = 0.20, 95% CI 0.05-0.72) and hyperbilirubinemia (TBil > 34 μmol/L) by 86% (OR = 0.14, 95% CI 0.03-0.50). Low-dose UDCA (≤ 10 mg/kg/day) within 12 months provided optimal bilirubin/hepatic improvement without dose-dependence. UDCA beyond 36 months nearly doubled TBA levels, potentially reflecting dose-dependent TBA elevation.
conclusionUDCA efficacy post-KPE is age-dependent. Low-dose therapy (≤ 10 mg/kg/day) within 12 months significantly improves jaundice and liver function, with limited benefits at 12-36 months. Use beyond 36 months may be harmful. Optimal timing/dosing requires prospective validation.
Indexed as
Identifiers
40884601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.