Evidence map›Paper›PMID 40884593›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Analysis of the value of novel inflammatory indicators derived from complete blood count in predicting for pertussis in children.

Jianyong Tang, Fang Wu, You Wu, Congcong Chen, Peiwen Ning, Wei Wang, Jianfei Shi, Xingyan Guo, Zengguo Wang

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jianyong Tang *Department of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Fang Wu *Department of Neurology, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
You Wu *Department of Neurology, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Congcong ChenDepartment of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Peiwen NingDepartment of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Wei WangDepartment of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Jianfei ShiDepartment of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Xingyan GuoXian Tieyizhong International Curriculum Center, Xi'an, 710021, Shaanxi, China.
Zengguo WangDepartment of Clinical Laboratory, Xi'an Children's Hospital, the Affiliated Children's Hospital of Xi'an Jiaotong University, No. 69 Xi Ju Yuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China. william_wzg@126.com.

Funding

National Natural Science Foundation of China 82172312
6 · The paper itself

Abstract

objectiveInflammatory indicators derived from complete blood count (CBC) have been shown to exhibit substantial clinical utility across a broad spectrum of infectious and inflammatory conditions, this study aimed to explore the potential value of CBC-derived inflammatory indicators in predicting for pertussis in children.

methodsCBC parameters of all the participants included in this study were collected. The CBC-derived inflammatory indicators evaluated included the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), [neutrophil + monocyte]-to-lymphocyte ratio (NMLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI). The predictive value of CBC-derived inflammatory indicators was assessed using the receiver operating characteristic (ROC) curve analysis.

resultsA total of 892 pertussis children, 903 children with non-pertussis respiratory tract infection and 1,165 healthy children were included in this study. Compared to healthy children, the PLR in children with pertussis was significantly reduced (p < 0.001), whereas the levels of the other indicators were significantly increased. Simultaneously, the indicators in children with pertussis were significantly lower than those in children with non-pertussis infection. In the comparative analysis of inflammatory indicators across different age subgroups, all indicators in the pertussis group were significantly elevated in children < 2 years old, compared to those in both the non-pertussis group and the healthy group; conversely, in children > 2 years old, these indicators were significantly lower than those observed in the non-pertussis group. The ROC analysis results indicated that, aside from PLR, the CBC-derived inflammatory indicators demonstrated significant value in predicting for pertussis infection in children < 2 years old. Furthermore, the integration of multiple markers could enhance diagnostic performance.

conclusionCBC-derived inflammatory indicators, particularly NLR and NMLR, may serve as valuable tools for early predicting for pertussis in children under 2 years old in clinical practice.

Indexed as

InflammationWhooping CoughBiomarkersBlood Cell CountChildChild, PreschoolFemaleHumansInfantMaleNeutrophilsPredictive Value of TestsROC CurveBiomarkersCBC-derived inflammatory indicatorsChildrenPertussisPredicting

Identifiers

PMID40884593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.