Evidence map›Paper›PMID 40884539›Full record

ArticlePflugers Archiv : European journal of physiology2025

Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension.

Alexandre Luz de Castro, Patrick Turck, Angela Maria Vicente Tavares, Custódio José Gaspar, Alan Bahr, Alexsandra Zimmer, Tânia Regina G Fernandes, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz, Sílvio Tasca and 5 more

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexandre Luz de CastroLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil. alexluzcastro@gmail.com.
Patrick TurckLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Angela Maria Vicente TavaresLaboratory of Cells, Tissues, and Genes, Hospital de Clínicas de Porto Alegre (HCPA), Ramiro Barcelos Street 2350, CEP 90035-003, Porto Alegre, RS, Brazil.
Custódio José GasparLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Alan BahrLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Alexsandra ZimmerLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Tânia Regina G FernandesLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Rafael Oliveira FernandesCardiovascular Health Across the Lifespan Program, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
Vanessa Duarte OrtizLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Sílvio TascaLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Elissa FernandesLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Daniela DrosdowskiLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Cristina Campos CarraroLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Adriane Belló-KleinLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.
Alex Sander da Rosa AraujoLaboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP 90035-003, Porto Alegre, RS, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial performance index (MPI) has been used in the estimation of ventricular function in a non-invasive way through echocardiography. This index has presented relevant results in clinical and experimental studies. However, there are no studies evaluating whether this index correlates with other cardiac parameters in experimental models of heart disease, such as monocrotaline-induced pulmonary artery hypertension (PAH) and acute myocardial infarction (AMI). In view of that, the present study evaluated rats submitted to PAH and perform a broad analysis of echocardiographic, hemodynamic and morphometric parameters of the right ventricle (RV) and pulmonary artery (PA). Besides that, the present study also evaluated rats submitted to experimental AMI and performed a broad echocardiographic evaluation of left ventricle (LV). Subsequently, it was analyzed whether the parameters collected presented correlation with the MPI. In PAH model, monocrotaline was administrated and the animals were divided into the following groups: control and PAH. In AMI model, infarction was induced by coronary artery ligation and the groups were as follows: SHAM and AMI. In PAH model, MPI presented correlation with RV functional parameters, as well as with parameters that evaluate flow and resistance in the PA. In addition, this index also presented correlation with LV parameters in infarcted rats. To our knowledge, this is the first study that evaluates the correlation of MPI with parameters of the RV in rats with PAH induce by monocrotaline. Besides that, this is the first study that compares the use of this index in two different experimental models of cardiac diseases.

Indexed as

Hypertension, PulmonaryMyocardial InfarctionAnimalsDisease Models, AnimalEchocardiographyHeart VentriclesHemodynamicsMaleMonocrotalinePulmonary ArteryRatsRats, WistarMonocrotalineEchocardiographyInfarctionMPIPulmonary hypertension

Identifiers

PMID40884539

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.