Evidence map›Paper›PMID 40884538›Full record

ArticlePflugers Archiv : European journal of physiology2025

AT

Wanessa M C Awata, Gustavo F Pimenta, Thales M H Dourado, Kathleen A Paulino, Marcela M Blascke de Mello, Lucas C Pinheiro, Michele M Castro, Carlos R Tirapelli

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wanessa M C AwataDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Gustavo F PimentaDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Thales M H DouradoDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Kathleen A PaulinoLaboratório de Farmacologia Cardiovascular, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, São Paulo, Brazil.
Marcela M Blascke de MelloDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Lucas C PinheiroDepartamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Michele M CastroDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Carlos R TirapelliLaboratório de Farmacologia Cardiovascular, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, São Paulo, Brazil. crtirapelli@usp.br.ORCID 0000-0002-9779-733X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304027/2017-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/24123-5
6 · The paper itself

Abstract

Sepsis enhances the anticontractile effect of perivascular adipose tissue (PVAT), which contributes to a reduced response to vasoconstrictor agents. In the early stages of sepsis, the renin-angiotensin-aldosterone system (RAAS) is activated, and this response can lead to poorer clinical outcomes. We hypothesized that AT

Indexed as

Adipose TissueNitric Oxide Synthase Type IIReceptor, Angiotensin, Type 1SepsisVasoplegiaAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsLosartanMaleNitric OxideRatsRats, WistarAngiotensin IIAngiotensin II Type 1 Receptor BlockersLosartanNitric OxideNitric Oxide Synthase Type IINos2 protein, ratReceptor, Angiotensin, Type 1AT1 receptorsINOSPerivascular adipose tissueRenin–angiotensin–aldosterone systemSepsisVasoplegia

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.