ReviewBiology of reproduction2026
The role of the aryl hydrocarbon receptor in ovarian development, function, xenobiotic metabolism, and disease†.
Review in Biology of reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Metabolic Calibration of Female Immune Plasticity: From X-Linked Vulnerability to Precision Metabotyping.Biology · 2026Review
- Pathogenic mechanisms and comprehensive therapeutic strategies of ovarian aging: targeting gut microbiota.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The aryl hydrocarbon receptor (AHR) plays a role in the development, function, and xenobiotic metabolism in multiple tissues, including the ovary. The AHR is a member of the Per/Arnt/Sim basic helix-loop-helix (bHLH) family of transcription factors. Endogenous and exogenous ligands activate the AHR signaling pathway. Activation of the AHR pathway leads to transcription of downstream targets. This review highlights the involvement that the AHR has in ovarian development and function. This review focuses on the involvement that the AHR has in both folliculogenesis and steroidogenesis, including the hypothalamic-pituitary-gonadal axis. Several studies indicate that the AHR mediates normal ovarian function and can influence xenobiotic metabolism in the ovary. Further, the review summarizes the involvement of the AHR in ovarian diseases such as infertility, polycystic ovarian syndrome, and ovarian cancer, and the potential for targeting the AHR as a therapeutic option for ovarian disease. Finally, this review addresses gaps in the literature that can be addressed to further the understanding of the role that the AHR has in the ovary and how its role can be leveraged in the clinic. This review examines the role that the aryl hydrocarbon receptor (AHR) plays in ovarian function (folliculogenesis, steroidogenesis, and xenobiotic metabolism) and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.