SynthesisJournal of burn care & research : official publication of the American Burn Association2026
Topical Heparin in Burns: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.
Synthesis in Journal of burn care & research : official publication of the American Burn Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The hidden battlefield: platelet function in the wake of severe trauma.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burns are associated with significant inflammation and pain. Topical agents like heparin can modulate these processes and improve outcomes. Our study aims to evaluate the effectiveness of using topical heparin (TH) in patients with burns. On August 7, 2024, we conducted a literature search on PubMed, Scopus, and Web of Science. Only randomized controlled studies were included. Data were extracted on analgesic drug usage, bleeding events, sepsis, visual analog scale pain scores, length of hospital stay, and mortality. Statistical analysis was performed using R software (version 4.4.1), heterogeneous data. Seven randomized controlled trials (503 patients; topical heparin: 249, control: 254) were included. Analgesic use (1-2 times/day: RR = 3.04, P = .68; 3-4 times/day: RR = 0.06, P = .18), bleeding (RR = 5.06, P = .37), sepsis (RR = 0.77, P = .40), hospital stay, and mortality (RR = 0.13, P = .90) showed no significant differences. Topical heparin reduced local wound infections by 60% (RR = 0.40, P < .01) and lowered Visual Analog Scale pain scores (MD = -3.34, P < .01). However, sensitivity analysis excluding an outlier nullified the pain reduction (MD = -4.17, P = .57). All studies had a high risk of bias, especially in outcome measurement and randomization. Topical heparin reduces pain and local wound infections in burn patients without having an impact on other outcomes. Evidence is limited by a high risk of bias. Well-designed randomized trials are needed to determine its broader clinical value.
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Registered trials
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