ArticleJournal of veterinary internal medicine
Untargeted Metabolic Profiling of Cat Urine and Plasma in Hypertension.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Untargeted Metabolic Profiling of Cat Urine and Plasma in Hypertension.Journal of veterinary internal medicineArticle
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Authors and funding
4 authors.
Funding
Abstract
backgroundEarly diagnosis of hypertension remains an important problem in cats. Lack of routine blood pressure screening in primary care practice, and the possibility of white coat artifact mean the discovery of a new diagnostic test, if less sensitive to short-term changes in blood pressure associated with veterinary care, would be useful. Identification of metabolomic changes in hypertensive cats could advance understanding of the pathogenesis of hypertension in cats, as well as identify novel biomarkers.
objectivesUse untargeted metabolomics to identify biochemical changes in cat plasma and urine between normotensive controls (NT) and hypertensive cats before treatment (HTpre); HTpre and hypertensive cats treated with amlodipine (HTtx). ANIMALS: Biobanked surplus plasma and urine samples were selected from client-owned cats (> 9 years old) that were NT (urine n = 17, plasma n = 19), HTpre (urine n = 13, plasma n = 19), or HTtx (urine n = 12, plasma n = 19).
methodsSamples were profiled using flow infusion electrospray-high-resolution mass spectrometry, and differences assessed using univariate (paired or two sample t-tests) and multivariate (partial least squares discriminant analysis) methods using the R-based MetaboAnalyst platform. Tentative identifications of metabolites then were made using the MZedDb database.
resultsSignificant (false discovery adjusted < 0.01) biochemical differences were observed between each of the sample groups. Biochemical changes in urine between HTpre and NT animals were linked to the tricarboxylic acid cycle, oxidative stress, steroid hormones, taurine metabolism, and phosphatidylinositol-3,4,5-trisphosphate.
conclusionsMetabolites altered in hypertensive cats were similar to those observed in other species.
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