SynthesisPathogens and global health2025
Global and regional mortality rate statistics of mpox (formerly monkeypox): a comprehensive systematic review and meta-analysis.
Synthesis in Pathogens and global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A hybrid machine learning framework with two-step feature selection for identifying key biomarkers and drug targets in monkeypox.Biochemistry and biophysics reports · 2026Article
- Mpox in Europe, 2022-2026: A Scoping Review of Viral Clades, Host Determinants of Severity and Antiviral Therapy.Viruses · 2026Article
- Monkeypox Virus (MPXV) Transmission Dynamics in Neighboring Countries as a Potential Threat to Kazakhstan.Viruses · 2026Review
- Tandem triplicate A29L peptide elicits robust immune responses against monkeypox virus in mice.Applied microbiology and biotechnology · 2026Article
- Mpox Seroprevalence in General Population Groups in South Kivu, Democratic Republic of the Congo: A Comparative Description Before and During the Clade Ib Outbreak.Open forum infectious diseases · 2026Article
- Computational Discovery of Novel Monkeypox Virus DNA Polymerase Inhibitors from the Zinc20 Database.Current issues in molecular biology · 2026Article
- 1-Hydroxy-1,8-napthyridinone (DHN) Analogs Potently Inhibit Monkeypox Virus Resolvase (Mpr).Journal of medicinal chemistry · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mortality trends associated with the mpox virus (MPXV) are not well defined. This study aims to systematically assess the mortality rate of mpox and its stratification across different geographical locations. Comprehensive review of articles from the PubMed, Embase, Scopus, and Web of Science databases up to June 2025, focusing on studies reporting mortality rates among patients diagnosed with mpox. A random-effects proportional meta-analysis assessed global and regional mpox mortality rates and their geographical variations. Sensitivity analysis using one-study removal method and meta-regression analyses were conducted. Out of 4,098 records, 30 articles met the selection criteria, comprising a total of 47,311 patients diagnosed with mpox. The pooled global mpox mortality rate was 3.1% (95% CI: 1.6%-5.9%). Mortality was significantly higher before 2016 at 11.4% (95% CI: 5.8%-21.1%), compared to 2.4% (95% CI: 1.2%-4.7%) during 2016-2025, and declined further in the post-COVID era to 1.5% (95% CI: 0.7%-3.4%). Mortality was markedly elevated among individuals with HIV co-infection (83.8%; 95% CI: 74.0%-90.5%). Regionally, mortality was highest in Africa (6.3%) and lowest in Europe (0.1%). Among studies conducted in endemic regions, a notable temporal decline was also observed, with mortality decreasing from 11.4% before 2016 to 4.1% during 2016-2025. Meta-regression identified year of publication as a significant predictor of mortality (
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