Evidence map›Paper›PMID 40884313›Full record

ReviewJournal of sleep research2026

Sleep Slow Wave-Bistability and the Connection Between the Sleeping Brain and the Environment-Neurobiological Considerations.

Péter Halász, Anna Szűcs, Carlotta Mutti, Liborio Parrino

Abstract readReview
In one paragraph

Review in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Péter HalászSzentágothai Doctoral School, Semmelweis University, Budapest, Hungary.
Anna SzűcsInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-9990-5787
Carlotta MuttiUnit of Neurology, Department of Medicine and Surgery, University of Parma, Parma, Italy.ORCID 0000-0002-1930-5045
Liborio ParrinoUnit of Neurology, Department of Medicine and Surgery, University of Parma, Parma, Italy.ORCID 0000-0002-4035-6234

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this paper is to review the phenomenon of bistability, a basic working mode of NREM sleep. The perpetual oscillations between two opposite states in sleep slow waves, K-complexes as well as in the Cyclic Alternating Pattern (CAP) on a different time scale; appear spontaneously and can also be elicited by sensory stimulation, representing a response of the sleeping brain. Although there is extensive literature on bistability, its significance remains obscure. In this paper, spontaneous and elicited bistable patterns are reviewed and the global presence of bistable oscillations in NREM sleep is highlighted. We discuss the relationship of bistability with sleep homeostasis and the overlap with the CAP, with emphasis on A1 phase. We collect data along the hypothesis that bistability would provide a perpetual and flexible interface between the sleeping brain and the environment across the night, protecting the continuity of sleep and, in parallel, preserving the brain's adaptive connection with the environment.

Indexed as

BrainEnvironmentSleepSleep, Slow-WaveSleep StagesElectroencephalographyHomeostasisHumansbistabilityCAP A1K complexsleep slow wave

Identifiers

PMID40884313
PMCPMC13003289

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.