Evidence map›Paper›PMID 40884287›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Mechano-Bactericidal Surfaces Achieved by Epitaxial Growth of Metal-Organic Frameworks.

Zhejian Cao, Santosh Pandit, Francoise M Amombo Noa, Jian Zhang, Wengeng Gao, Shadi Rahimi, Lars Öhrström, Ivan Mijakovic

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mechano-Bactericidal Surfaces Achieved by Epitaxial Growth of Metal-Organic Frameworks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhejian CaoDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.ORCID https://orcid.org/0000-0002-3216-6270
Santosh PanditDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.
Francoise M Amombo NoaDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.ORCID https://orcid.org/0000-0001-8361-3432
Jian ZhangDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.
Wengeng GaoDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.
Shadi RahimiDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.
Lars ÖhrströmDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.ORCID https://orcid.org/0000-0002-6420-2141
Ivan MijakovicDepartment of Life Sciences, Chalmers University of Technology, Gothenburg, SE-41296, Sweden.

Funding

Independent Research Fund Denmark DFF3164-00026BKnut and Alice Wallenberg Foundation: WISE Postdoc GrantNordForsk 105121Novo Nordisk Foundation NNF20CC0035580Vetenskapsrådet 2020-04096Vetenskapsrådet 2023-05111
6 · The paper itself

Abstract

Mechano-bactericidal (MB) surfaces have been proposed as an emerging strategy for preventing biofilm formation. Unlike antibiotics and metal ions that chemically interfere with cellular processes, MB nanostructures cause physical damage to the bacteria. The antibacterial performance of artificial MB surfaces relies on rational control of surface features, which is difficult to achieve for large surfaces in real-life applications. Herein, a facile and scalable method is reported for fabricating MB surfaces based on metal-organic frameworks (MOFs) using epitaxial MOF-on-MOF hybrids as building blocks with nanopillars of less than 5 nm tip diameter, 200 nm base diameter, and 300 nm length. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, result in surfaces with nanopillars in different orientations, both presenting MB actions (bactericidal efficiency of 83% for E. coli). Distinct MB mechanisms, including stretching, impaling, and mechanical injury, are discussed with the observed bacterial morphology on the obtained MOF surfaces.

Indexed as

Anti-Bacterial AgentsEscherichia coliMetal-Organic FrameworksBiofilmsNanostructuresSurface PropertiesAnti-Bacterial AgentsMetal-Organic Frameworksantibacterialsbiofilmmechano‐bactericidal surfacemetal–organic frameworkMOF‐on‐MOF

Identifiers

PMID40884287
PMCPMC12697766

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.