ArticleJournal of animal science2025
Oral tryptophan supplementation to suckling piglets affecting hypothalamic serotonin metabolism, behavior, and growth in the nursery period under social mixing stress.
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploring finger millet as an underutilised African indigenous grain crop for functional food development, sustainable nutrition, and health.Frontiers in nutrition · 2026Review
- The Weaning of Pigs: Mechanistic Outcomes to Intestinal Immunity and Integrity.Animal science journal = Nihon chikusan GakkaihoReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Tryptophan (Trp) is the rate-limiting substrate for the synthesis of serotonin (5-hydroxytryptamine; 5-HT) in the brain, which plays a central role in the regulation of stress sensitivity and feed intake. The objective of this study was to evaluate the effect of oral Trp supplementation to suckling piglets on 5-HT metabolism, growth performance, and behavior during the suckling (14 to 21 d of age) and nursery (21 to 56 d of age) periods, under social mixing stress at weaning. Eighty 14-d-old suckling piglets from 10 sows (8 piglets per litter) were allotted to 2 treatments. The 2 treatments (0.389 g alanine + 0.430 g glucose/kg body weight (BW)/d or 0.467 g Trp/kg BW/d) were given orally to piglets 7 times daily, beginning at 0700 h in 2 h intervals, from day 14 to day 21 of age (suckling period). Alanine (Ala) was used to balance the nitrogen content when Trp was added. Growth performance was measured from day 14 to day 21 of age (suckling period) and from day 21 to day 56 of age (nursery period) in 2 phases. On day 21, 12 piglets from 12 L (6 pigs/treatment) were selected and euthanized to collect hypothalamus to measure 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentrations. The remaining piglets were weaned and moved to nursery pens. Pigs within the same treatment and sex, but from different litters, were paired and housed together (2 pigs/pen). All pigs were fed the same diet during the nursery period. Normal and aggressive behaviors were recorded for 24 h immediately after weaning. Oral Trp supplementation during the suckling period increased (P < 0.05) hypothalamic concentration of 5-HT and 5-HIAA at weaning, whereas growth performance was not affected. However, oral Trp supplementation tended to increase (P = 0.057) the frequency of visits to the feeders during social mixing stress. In conclusion, oral Trp supplementation during the suckling period increased hypothalamic serotonin and could influence eating behavior postweaning.
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Registered trials
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