ArticleJournal of the American Heart Association2025
Assessment of Ventriculo-Arterial Interactions in Early and Undifferentiated Pulmonary Hypertension Using Wave Intensity Analysis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
backgroundPulmonary wave intensity analysis uses pressure and velocity data to assess the intensity, direction, type, and timing of waves. Its application in early and undifferentiated pulmonary hypertension (PH) to characterize right ventricular (RV)-pulmonary arterial (PA) interactions has not been previously reported.
methodsWe hypothesized that wave intensity and speed would increase with mean PA pressure, while reflected wave timing would remain unchanged. Sixty patients with suspected PH underwent same-day right heart catheterization and cardiac magnetic resonance. PA pressure and pulmonary vascular resistance were measured via right heart catheterization; PA flow, RV volumes, and function were assessed by cardiac magnetic resonance. Wave intensity analysis was derived from pressure and velocity changes. Linear and logistic regression were used for analysis.
resultsOf the 60 patients (6 with mean PA pressure <20 mm Hg, 11 undifferentiated, 43 confirmed PH), all exhibited forward compression and decompression waves. A backward compression wave was present in 95%, while a backward decompression wave was found in 32%. Intensities of all 4 dominant waves increased with mean PA pressure (
conclusionsIn early and undifferentiated PH, peak wave intensity and speed increases with mean PA pressure, while reflected wave timing is unchanged. Wave intensity analysis metrics may aid in detecting PA stiffening before overt hemodynamic or structural RV changes.
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