Evidence map›Paper›PMID 40884048›Full record

ArticleAmerican journal of hematology2025

Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion.

Mahmoud Mikdar, Estela Shabani, Christof Grüring, Mudit Chaand, Usheer Kanjee, Jonathan M Goldberg, Slim Azouzi, Jacob A Tennessen, Brendan Elsworth, Cyrianne Keutcha and 3 more

Abstract read
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In one paragraph

Article in American journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mahmoud MikdarDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-3449-2851
Estela ShabaniDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Christof GrüringDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Mudit ChaandDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Usheer KanjeeDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-3169-4557
Jonathan M GoldbergDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Slim AzouziUniversité de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France.ORCID 0000-0001-5519-4031
Jacob A TennessenDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Brendan ElsworthDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Cyrianne KeutchaDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Natasha S BartenevaDepartment of Pediatrics, Harvard Medical School and PCMM, Boston Children's Hospital, Boston, Massachusetts, USA.
John G DoenchBroad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-8534-5515

Funding

Functional analysis of red blood cell determinants of Plasmodium invasionR01HL139337 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2017 to 2020
$2.3M
Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infectionR01AI140751 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2018 to 2022
$2.0M
American Heart Association 23POST1017743National Heart Lung and Blood Institute 5R01HL139337National Institute of Allergy and Infectious Diseases 5R01AI140751NHLBI NIH HHS R01 HL139337NIAID NIH HHS R01 AI140751Schweizerischer Nationalfonds zur Frderung der Wissenschaftlichen Forschung P300P3_151146Schweizerischer Nationalfonds zur Frderung der Wissenschaftlichen Forschung PBSKP3_140144
6 · The paper itself

Abstract

Malaria continues to pose significant health challenges globally despite advances in control measures. Plasmodium falciparum, the parasite responsible for most severe malaria cases, uses multiple redundant invasion pathways to enter the red blood cell (RBC) during the blood stage of infection. Through a combination of RNA interference screening in erythroid cells and validation by CRISPR/Cas9-mediated knockout in primary human hematopoietic stem cells, we identified the glycosyltransferase Core 1 Synthase Glycoprotein-N-Acetylgalactosamine 3-Beta-Galactosyltransferase 1 (C1GALT1) as a novel host determinant for P. falciparum invasion. Analyses of C1GALT1-deficient cultured reticulocytes and RBCs with the glycophorin A/B-null M

Indexed as

Antigens, Tumor-Associated, CarbohydrateGalactosyltransferasesMalaria, FalciparumPlasmodium falciparumErythrocytesGene Knockout TechniquesHematopoietic Stem CellsHumansN-Acetylneuraminic AcidPlasmodium knowlesiPrimary Cell CultureAntigens, Tumor-Associated, CarbohydrateC1GALT1 protein, humanGalactosyltransferasesN-Acetylneuraminic Acidsialosyl-Tn antigenC1GALT1Plasmodium falciparumred blood cellsRNAi screensialyl‐T antigen

Identifiers

PMID40884048
PMCPMC12731253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.