Evidence map›Paper›PMID 40884038›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Generalizing Vinyl Halide Cross-Coupling Reactions with Photoredox and Photoredox/Nickel Dual Catalysis.

Kousik Das, Nayan Saha, Zhuofan Li, Indrajit Ghosh, Burkhard König

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kousik DasFakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.
Nayan SahaFakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.
Zhuofan LiFakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.
Indrajit GhoshFakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.ORCID https://orcid.org/0000-0002-5127-2271
Burkhard KönigFakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany.ORCID https://orcid.org/0000-0002-6131-4850

Funding

Deutsche Forschungsgemeinschaft 325-444632635
6 · The paper itself

Abstract

Reliable, broadly applicable cross-coupling conditions that deliver the desired products with minimal optimization are essential in pharmaceutical research, where efficient synthesis accelerates lead discovery and late-stage diversification. Although advances like high-throughput additive screening and commercial catalyst/ligand libraries improve prediction in specific systems, a general strategy for vinyl halide cross-coupling across diverse bond-forming reactions remains elusive. Herein, we report a general and highly predictable method for vinyl halide cross-coupling under photoredox conditions, employing two complementary catalytic systems. In the first, the organic photocatalyst 4CzIPN enables efficient coupling with nucleophiles such as thiols, selenols, sulfinate salts, activated alkenes, phosphorus (III), and boron compounds, affording C(sp

Indexed as

Cross‐couplingGeneral methodNickelPhotoredoxVinyl halide

Identifiers

PMID40884038
PMCPMC12518699

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.