ReviewThe New phytologist2025
An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.
Review in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Endogenous Multilayer Control of Cambial Stem Cells and Its Consequences for Wood Formation.Plants (Basel, Switzerland) · 2026Review
- Regulatory Mechanisms Underlying Stem Strength and Toughness in Dicotyledonous Plants: Implications for Soybean Breeding.Current issues in molecular biology · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Non-cell autonomous signalling is a mechanism by which stem cells are maintained across the tree of life. In plants, many stem cell populations are regulated by peptide ligands related to CLAVATA3, which are secreted from one cell type and bind to the leucine-rich repeat domain of a plasma-membrane-localised receptor kinase related to CLAVATA1 in an adjacent cell type. Activation of CLAVATA1-like receptors then leads to a suite of events regulating stem cell fate. The vascular cambium, the meristem from which xylem and phloem are derived, is no different in this respect. Here, TRACHEARY ELEMENT DIFFERENTIATION FACTOR (TDIF) peptide is excreted from phloem cells and binds to the PHLOEM INTERCALATED WITH XYLEM (PXY) receptor kinase, which in turn leads to activation of a suite of factors that influence xylem and phloem production. In 2016, we reviewed the literature that described signalling components, phytohormones and transcription factors that interacted with TDIF and PXY. In the intervening period, our understanding of these interactions has significantly progressed and here we provide an update, describing how TDIF and PXY promote growth while maintaining pattern in the stem cell populations that they regulate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.