ArticleArthritis care & research2026
Preferences for Posttraumatic Osteoarthritis Prevention Strategies in Individuals With Anterior Cruciate Ligament Injury.
Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
objectiveThere is growing interest in evaluating new strategies to delay or prevent posttraumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
methodsParticipants with a history of ACL injury were recruited from Reddit, Facebook, and ResearchMatch.org. After consent and eligibility confirmation, participants completed a survey comprising questions on (1) demographics, (2) PTOA perceptions, (3) perceived PTOA risk, and (4) a discrete choice experiment (DCE) task. The DCE assessed treatment attributes including risk reduction, side effects, benefits, and out-of-pocket costs. In several scenarios, participants chose between two hypothetical treatments with various attributes or no treatment. The data were analyzed with multinomial logit, mixed logit, and latent class models.
resultsWe enrolled 273 participants (median age 30.6 years [interquartile range 27-33]; 63% female; mean body mass index = 25.5 kg/m
conclusionThese results can be used to develop tailored recruitment messaging for future trials. Messaging should emphasize how to manage side effects and out-of-pocket costs.
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