ArticleInfectious agents and cancer2025
Porphyromonas gingivalis and Fusobacterium nucleatum synergistically strengthen the effect of promoting oral squamous cell carcinoma progression.
Article in Infectious agents and cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- Periodontitis as a Modulator of Malignant Transformation in Oral Potentially Malignant Disorders: A Narrative Review of Biological Mechanisms and Clinical Implications.Current oncology reports · 2026Review
- Article
- Genetics and Molecular Mechanisms in Oral Squamous Cell Carcinoma: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Review
- The Presence and Tissue Distribution ofInternational journal of dentistry · 2026Article
- Role of Gut Microbiome in Oncogenesis and Oncotherapies.Cancers · 2025Review
- Microbial dysbiosis and host-microbe interactions in proliferative verrucous leukoplakia: insights into carcinogenic potential.Archives of microbiology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo investigate the mechanism of action of Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) individually and synergistically on Cal-27 cells through transcriptome analyses to evaluate the mechanism evidence of periodontal pathogen involvement in oral squamous cell carcinoma.
methodsCal-27 cells were treated with P. gingivalis and F. nucleatum individually or in combination. Cell proliferation was assessed via CCK-8 assay and EdU staining, while migration was evaluated using scratch assays. Transcriptomic sequencing analyzed molecular mechanisms underlying single and co-infections.
resultsSynergistic treatment with P. gingivalis and F. nucleatum significantly enhanced Cal-27 cell proliferation and migration compared to either pathogen alone. Transcriptomics revealed that co-infection accelerated tumor cell cycle progression and amplified pro-inflammatory pathways, indicating stronger pro-tumorigenic effects.
conclusionThis study clarifies the cooperative tumor-promoting role of multiple bacterial species, providing potential therapeutic targets for oral squamous cell carcinoma in bacterial infection contexts and highlighting the importance of controlling oral microbiota.
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Registered trials
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