SynthesisBMC urology2025
Stem cell therapy for erectile dysfunction: promise or reality? - a systematic review and meta-analysis of clinical trials.
Synthesis in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Evaluation of the efficacy of conditioned medium derived from quality- and quantity-cultured peripheral blood mononuclear cells for erectile dysfunction.Regenerative therapy · 2026Article
- Stem cell therapy for erectile dysfunction: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- Penile Rehabilitation After Surgery for Prostate Cancer: An Umbrella Review on Traditional Approaches and Novel Perspectives.Journal of clinical medicine · 2026Review
- Erectile dysfunction and Peyronie's disease: from biologics to nanomedicine-enabled therapies.Sexual medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe outcomes of clinical trials on stem cell therapy (SCT) on erectile dysfunction (ED) treatment are promising but there is still no conclusive evidence regarding its efficacy. The aim of this meta-analysis is to compile studies that assess the effectiveness of SCT on ED to reach a more reliable conclusion.
methodsThe meta-analysis was registered to PROSPERO (CRD42024540511). We utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline to report the outcomes. Articles published from January 2000 to May 2024 were included for systematic review. We performed a systematic search using keywords: "stem cell" AND ("erectile dysfunction" OR "erectile function" OR "erection" OR "impotence").
resultsWe initially identified 2,013 studies in full publications or abstracts using the search terms. Eleven studies were included in systematic review and six of them were included in meta-analysis. Most studies included in systematic review reported improvements in erectile function following intracavernosal SCT. The meta-analysis revealed significant improvements at six months in international index of erectile function-5 (IIEF-5), international index of erectile function-erectile function domain) IIEF-EF, erectile hardness score (EHS), and peak systolic velocity (PSV) (p < 0.05). End-diastolic velocity (EDV) increased significantly at 3 months (p = 0.031) but not at six months (p = 0.868). Heterogeneity ranged from low to high (I² = 0-71.2%). No significant publication bias was detected (Egger's test p > 0.05).
conclusionIntracavernosal SCT may increase scores on the questionnaires evaluated compared to baseline at six months which currently represent the longest reported follow-up duration but comparative trials with longer follow-up periods are needed to draw more definitive conclusions and reveal long-term effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.