ArticleOdontology2026
miR-511-5p is a potential biomarker of periodontitis and inhibits the inflammatory response via targeting SOST.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Periodontitis seriously affects oral health and quality of life. MiRNAs have demonstrated a key role in regulating gene expression. To analyze and explore the expression characteristics of miR-511-5p in periodontitis and its potential mechanism of action. This study screened for miRNAs using the GSE89081 dataset. Clinical samples were collected to measure the expression levels of miR-511-5p. The diagnostic potential of miR-511-5p in periodontitis was evaluated through receiver operating characteristic (ROC) curve analysis. TargetScan was employed to predict the downstream target genes of miR-511-5p. The direct interaction between miR-511-5p and SOST was validated using a dual-luciferase reporter assay. Their correlation was assessed using Pearson correlation analysis. Cell viability was assessed by CCK-8 assay. IL-6, IL-1β, and TNF-α expression levels were quantified using RT-qPCR and ELISA assays. miR-511-5p was downregulated in the gingival crevicular fluid obtained from patients with periodontitis. The ROC curve analysis revealed that miR-511-5p could effectively discriminate between patients with periodontitis and healthy controls. SOST has been identified as a downstream target gene of miR-511-5p. The binding interaction between them was validated through a dual-luciferase reporter assay, and the Pearson correlation analysis revealed a negative correlation. The mimic of miR-511-5p enhanced the proliferation of PDLCs and suppressed the LPS-induced expression of IL-6, IL-1β, and TNF-α, whereas overexpression of SOST exerts opposing effects. miR-511-5p, as a potential biomarker for periodontitis, inhibited the proliferation and inflammatory response of PDLCs by negatively regulating SOST through targeting.
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