Evidence map›Paper›PMID 40883627›Full record

SynthesisGeroScience2026

Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.

Zheng Long Lee, Jesse Jianyi Li, Savannah Kiah Hui Siew, Charly Hugo Alexandre Billaud, Junhong Yu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zheng Long LeePsychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore. zlee049@e.ntu.edu.sg.ORCID 0009-0009-4006-2365
Jesse Jianyi LiPsychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore.ORCID 0009-0004-1280-5508
Savannah Kiah Hui SiewPsychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore.ORCID 0000-0003-1927-3845
Charly Hugo Alexandre BillaudPsychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore.ORCID 0009-0001-3466-9963
Junhong YuPsychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore.ORCID 0000-0002-2563-9658

Funding

Nanyang Technological University 021080-00001
6 · The paper itself

Abstract

Two decades of task-based fMRI studies have revealed atypical task-related activation and hypoactivation patterns in Alzheimer's disease (AD) and mild cognitive impairment (MCI), implicating the impaired cognitive processing observed in these neurocognitive disorders. The current coordinate-based meta-analysis provides an updated picture of the pathophysiological neurocognitive mechanisms implicated in MCI and AD, which better controls for false positive findings. To pool and summarise these findings, we conducted activation likelihood estimation (ALE) meta-analyses on 90 eligible studies (N

Indexed as

Alzheimer DiseaseBrainCognitive DysfunctionMagnetic Resonance ImagingAgedBrain MappingHumansLikelihood FunctionsALE meta-analysisAlzheimer’s diseaseBrain activationMild cognitive impairmentTask-based fMRI

Identifiers

PMID40883627
PMCPMC12972504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.