ReviewArchives of toxicology2025
Construction of testicular organoids and their applications in the field of toxicology.
Review in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bridging the Gap: How environmental exposures compromise male fertility and clinical Outlook.Current research in toxicology · 2026Review
- Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The decline in male sperm quality significantly contributes to infertility among couples of reproductive age, threatening human reproductive health. Environmental pollutants are one of the key contributors, driving research into their mechanisms and potential solutions. Although animal and cell models are commonly used to study reproductive toxicity, they have their limitations. Testicular organoids are new in vitro models that can replicate the structure and function of testes, providing a promising platform for toxicity assessments. Despite advancements, challenges persist in standardization, development techniques, and practical applications. This article systematically reviews how factors such as cell densities, 3D culture platforms, and preservation conditions influence the construction of testicular organoids. We summarize and discuss the optimal methods and conditions for constructing testicular organoids. It also reviews their applications in evaluating the toxic effects of environmental endocrine disruptors and screening drugs for reproductive toxicity. This review offers references and insights that support the development of testicular organoid technology and its potential applications in toxicology.
Indexed as
Identifiers
40883615What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.