Evidence map›Paper›PMID 40883602›Full record

ArticleScientific reports2025

Longitudinal retinal functional evaluation using full-field electroretinography in New Zealand white and Dutch Belted rabbits with aging.

Van Phuc Nguyen, Yeachan Lee, Zhuying Wei, Mi Zheng, Khoi Tran, Graham Lippincott, Wei Zheng, Y Eugene Chen, Dongshan Yang, Yannis M Paulus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Van Phuc Nguyen *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA.
Yeachan Lee *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA.
Zhuying WeiCenter for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA.
Mi ZhengDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA.
Khoi TranDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Graham LippincottDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Wei ZhengDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Y Eugene ChenCenter for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA.
Dongshan YangCenter for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA. doyang@med.umich.edu.
Yannis M PaulusDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA. ypaulus1@jh.edu.

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
IDOL and dyslipidemia in cardiovascular diseasesR01HL147527 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2019 to 2022
$3.1M
Multimodal Molecular Imaging of Choroidal NeovascularizationR01EY034325 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yannis Mantas Paulus, XUEDING WANG · 2023 to 2026
$2.5M
Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug DeliveryR01EY033000 · NEI · PURDUE UNIVERSITY · PI LEE, CHI HWAN, PAULUS, YANNIS MANTAS · 2021 to 2025
$1.9M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
A novel rabbit model for easy monoclonal antibody productionR21GM140359 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASCALHO, MARILIA ISABEL, YANG, DONGSHAN · 2020 to 2021
$429k
Genome Editing Therapy for Usher Syndrome Type 3R42EY035582 · NEI · GENETOBE INC. · PI IANNUZZI, MICHAEL C, YANG, DONGSHAN · 2023 to 2023
$290k
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01-HL147527Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R21 GM140359-01NEI NIH HHS K08 EY027458NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY033000NEI NIH HHS R01 EY034325NEI NIH HHS R42 EY035582NHLBI NIH HHS R01 HL147527NIGMS NIH HHS R21 GM140359U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) 1K08EY027458U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) 1R01EY033000U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) 1R42EY035582-01U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY034325U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) 1R42EY035582
6 · The paper itself

Abstract

Electroretinography (ERG) is pivotal in elucidating retinal function, yet investigations into the temporal dynamics of ERG signals in New Zealand White (NZW) and Dutch-belted (DB) rabbits remain scarce. This study presents a longitudinal assessment of retinal function in both NZW and DB strains. ERG recordings were conducted on four NZW and four DB rabbits at 2, 7, 15, and 24 months of age, encompassing both dark-adapted and light-adapted protocols at each time point. Quantitative analyses included assessment of a- and b-wave amplitudes, implicit times, and photopic flicker responses. Results revealed consistently stronger a- and b-wave amplitudes in NZW rabbits compared to DB rabbits across all time points. These stronger ERG responses likely result from increased effective light exposure at the photoreceptor level in NZW rabbits, rather than indicating intrinsic differences in retinal sensitivity. Over time, NZW rabbits showed a decline in visual function of the cone and postreceptoral systems, with the rod system less affected. In contrast, the visual function of DB rabbits initially improved at an early stage, followed by a slight decline after 15 months. The differences between the two strains may be attributed to the varying speeds of retinal maturation, melanin's absorption of light, and its protective effect against light-induced retinal damage. This dataset underscores the differential retinal characteristics between NZW and DB rabbits, shedding light on their distinct functional profiles.

Indexed as

AgingElectroretinographyRetinaAnimalsMalePhotic StimulationRabbitsRetinal Cone Photoreceptor Cells

Identifiers

PMID40883602
PMCPMC12397238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.