Evidence map›Paper›PMID 40883591›Full record

ArticleCommunications biology2025

Ovalbumin-induced asthma leads to bone loss with Piezo channel suppression in mice.

Weiqi Gao, Takeshi Sawada, Ailin Cao, Reiko U Yoshimoto, Yu Yamaguchi, Yukie Takahashi, Takaichi Fukuda, Yasuyoshi Ohsaki, Reona Aijima, Tomoko Kadowaki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weiqi GaoDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.
Takeshi SawadaDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.
Ailin CaoDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.
Reiko U YoshimotoDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.ORCID http://orcid.org/0000-0001-8081-8926
Yu YamaguchiDepartment of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yukie TakahashiDepartment of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Takaichi FukudaDepartment of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yasuyoshi OhsakiDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.
Reona AijimaDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan.
Tomoko KadowakiDepartment of Frontier Oral Science, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Takayuki TsukubaDepartment of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Mizuho A KidoDivision of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga, Japan. kido@cc.saga-u.ac.jp.ORCID http://orcid.org/0000-0002-9348-0706

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP20K21683MEXT | Japan Society for the Promotion of Science (JSPS) JP24K23594
6 · The paper itself

Abstract

The impact of allergic diseases on bone loss remains unclear because it is considered to result from the use of corticosteroids to ameliorate allergic inflammation. To explore the effects of allergic diseases on bone metabolism, we investigated long bones in ovalbumin (OVA)-induced asthmatic mice. Compared with that of vehicle-treated controls, the bone mass of OVA-induced asthmatic mice was lower. We found fewer mature osteoblasts on the surfaces of the cortical and trabecular bones of allergen-sensitized mice than in those of vehicle-treated mice. Piezo1 and Piezo2 were located in mature osteoblasts, and their expression levels decrease during osteocytogenesis. Compared with that in non-asthmatic mice, the expression levels of both Piezo1 and Piezo2 were suppressed in asthmatic mice. The Piezo1 agonist reversed OVA-induced bone loss, with increased osteogenesis and type I collagen (Col1) expression. Furthermore, compared with control mice, Piezo2 heterozygous deletion mice with OVA presented a decreased bone volume. Our data suggest that asthma could induce osteopenia and that Piezo channel modulation could be a possible way to prevent bone loss induced by allergic asthma.

Indexed as

AsthmaIon ChannelsOvalbuminAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLOsteoblastsOsteogenesisIon ChannelsOvalbuminPiezo1 protein, mousePiezo2 protein, mouse

Identifiers

PMID40883591
PMCPMC12397299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.